Natural Compound Licochalcone B Induced Extrinsic and Intrinsic Apoptosis in Human Skin Melanoma (A375) and Squamous Cell Carcinoma (A431) Cells
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"Natural Compound Licochalcone B Ind..." refers background in this paper
...The two main apoptotic pathways are the extrinsic [death receptor (DR)] pathway and the intrinsic (mitochondrial) pathway (Elmore, 2007)....
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7,255 citations
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...Hengartner MO. 2000....
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...Cohen GM. 1997....
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4,556 citations
"Natural Compound Licochalcone B Ind..." refers background in this paper
...…activation of caspase 8 leads to cleavage of Bid and Bcl-2 family proteins such as Bax and Bak and promotes the release of cytochrome c from the mitochondria to the cytosol (Li et al., 1998; Luo et al., 1998; Scaffidi et al., 1998), which mediates apoptosis in the extrinsic and intrinsic pathways....
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"Natural Compound Licochalcone B Ind..." refers background in this paper
...…activation of caspase 8 leads to cleavage of Bid and Bcl-2 family proteins such as Bax and Bak and promotes the release of cytochrome c from the mitochondria to the cytosol (Li et al., 1998; Luo et al., 1998; Scaffidi et al., 1998), which mediates apoptosis in the extrinsic and intrinsic pathways....
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