Journal ArticleDOI
Natural History of Hepatitis C
David L. Thomas,Leonard B. Seeff +1 more
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TLDR
Results of ongoing nonconcurrent studies are needed to determine disease progression in the third, fourth, and fifth decades of infection and to better define the factors that affect progression.About:
This article is published in Clinics in Liver Disease.The article was published on 2005-08-01. It has received 342 citations till now. The article focuses on the topics: Hepatitis C & Hepatitis C virus.read more
Citations
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Diagnosis, management, and treatment of hepatitis C: An update
TL;DR: This document has been approved by the AASLD, the Infectious Diseases Society of America, and the American College of Gastroenterology.
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IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy
Vijayaprakash Suppiah,Max Moldovan,Golo Ahlenstiel,Thomas Berg,Martin Weltman,Maria Lorena Abate,Margaret F. Bassendine,Ulrich Spengler,Gregory J. Dore,Gregory J. Dore,Elizabeth E. Powell,Elizabeth E. Powell,Stephen M. Riordan,David Sheridan,Antonina Smedile,Vincenzo Fragomeli,Tobias Müller,Melanie Bahlo,Graeme J. Stewart,David R. Booth,Jacob George +20 more
TL;DR: The data suggest that host genetics may be useful for the prediction of drug response, and they also support the investigation of the role of IL28B in the treatment of HCV and in other diseases treated with IFN-α.
Journal ArticleDOI
The Increasing Burden of Mortality From Viral Hepatitis in the United States Between 1999 and 2007
TL;DR: By 2007, HCV had superseded HIV as a cause of death in the United States, and deaths from HCV and HBV disproportionately occurred in middle-aged persons, requiring new policy initiatives to detect patients with chronic hepatitis and link them to care and treatment.
Journal ArticleDOI
Eradication of Hepatitis C Virus Infection and the Development of Hepatocellular Carcinoma: A Meta-analysis of Observational Studies
Rebecca L. Morgan,Brittney Baack,Bryce D. Smith,Anthony Yartel,Marc Pitasi,Yngve Falck-Ytter +5 more
TL;DR: A systematic review of the evidence is needed to assess the benefits of treatment of hepatitis C virus (HCV)-infected persons on development of hepatocellular carcinoma (HCC).
Journal Article
Eradication of Hepatitis C Virus Infection and the Development of Hepatocellular Carcinoma
Rebecca L. Morgan,Brittney Baack,Bryce D. Smith,Anthony Yartel,Marc Pitasi,Yngve Falck-Ytter +5 more
TL;DR: Sustained virologic response after treatment among HCV-infected persons at any stage of fibrosis is associated with reduced HCC, and the evidence was determined to be of moderate quality.
References
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Journal ArticleDOI
Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults.
TL;DR: Current patterns of overweight and obesity in the United States could account for 14 percent of all deaths from cancer in men and 20 percent of those in women, and increased body weight was associated with increased death rates for all cancers combined and for cancers at multiple specific sites.
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Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome
TL;DR: A random-primed complementary DNA library was constructed from plasma containing the uncharacterized non-A, non-B hepatitis agent and screened with serum from a patient diagnosed with NANBH, showing consistent with the agent being similar to the togaviridae or flaviviridae.
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Histological grading and staging of chronic hepatitis.
Kamal G. Ishak,Amelia Baptista,Leonardo Bianchi,Francesco Callea,Jan De Groote,Fred Gudat,Helmut Denk,Valeer Desmet,Gerhard Korb,R. N. M. Macsween,M. James Phillips,Bernard G. Portmann,H. Poulsen,Peter J. Scheuer,Martin Schmid,Heribert Thaler +15 more
TL;DR: This research presents a meta-analysis of Anatomia e Istologia Patologica, a large quantity of which has never before been published in a peer-reviewed journal, which aims to provide real-time information about the immune system’s response to disease.
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An algorithm for the grading of activity in chronic hepatitis C
Pierre Bedossa,Thierry Poynard +1 more
TL;DR: A simple algorithm that generates a single activity score based on basic pathological features in chronic hepatitis C is proposed and tested, showing its accuracy is as high as that obtained using a statistical approach.
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Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis
Robert G. Knodell,Kamal G. Ishak,William C. Black,Thomas S. Chen,Robert M. Craig,Neil Kaplowitz,T Kiernan,Jerome Wollman +7 more
TL;DR: A Histology Activity Index has been developed which generates a numerical score for liver biopsy specimens obtained from patients with asymptomatic chronic active hepatitis that provides definitive endpoints for statistical analysis of serial changes in liver histology and offers an alternative to the use of conventional pathological descriptions.