Natural killer cell deficiency.
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TLDR
Clinicians have added clarity to this diagnosis and identified defects in 3 genes that can cause NK cell deficiency, as well as some of the underlying biology.Abstract:
Natural killer (NK) cells are part of the innate immune defense against infection and cancer and are especially useful in combating certain viral pathogens. The utility of NK cells in human health has been underscored by a growing number of persons who are deficient in NK cells and/or their functions. This can be in the context of a broader genetically defined congenital immunodeficiency, of which there are more than 40 presently known to impair NK cells. However, the abnormality of NK cells in certain cases represents the majority immunologic defect. In aggregate, these conditions are termed NK cell deficiency. Recent advances have added clarity to this diagnosis and identified defects in 3 genes that can cause NK cell deficiency, as well as some of the underlying biology. Appropriate consideration of these diagnoses and patients raises the potential for rational therapeutic options and further innovation.read more
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NK cells and cancer: you can teach innate cells new tricks
Maelig G. Morvan,Lewis L. Lanier +1 more
TL;DR: Evidence for the role of NK cells in immune surveillance against cancer and new therapeutic approaches for targetingNK cells in the treatment of cancer are reviewed.
Journal ArticleDOI
Natural Killer Cells: Development, Maturation, and Clinical Utilization
Alex M. Abel,Alex M. Abel,Chao Yang,Chao Yang,Monica S. Thakar,Monica S. Thakar,Subramaniam Malarkannan +6 more
TL;DR: Recent advances made in the understanding of how NK cells develop, mature, and their potential translational use in the clinic are summarized.
Journal ArticleDOI
NK cells for cancer immunotherapy.
TL;DR: New approaches to activate NK cells, increase their proliferation in vivo and increase their capacity to recognize tumour cells are discussed.
Iconographies supplémentaires de l'article : Practice parameter for the diagnosis and management of primary immunodeficiency
Francisco A. Bonilla,David A. Khan,Zuhair K. Ballas,Javier Chinen,Michael M. Frank,Joyce T. Hsu,Michael D. Keller,Lisa Kobrynski,Hirsh D. Komarow,Bruce Mazer,Robert P. Nelson,Jordan S. Orange,John M. Routes,William T. Shearer,Ricardo U. Sorensen,James W. Verbsky,David I. Bernstein,Joann Blessing-Moore,David Lang,Richard A. Nicklas,John Oppenheimer,Jay M Portnoy,Christopher Randolph,Diane E. Schuller,Sheldon L. Spector,S. Tilles,Dana V. Wallace,D.A. Khan +27 more
TL;DR: This document incorporated the efforts of many participants, and no single individual, including those who served on the Joint Task Force, is authorized to provide an official AAAAI or ACAAI interpretation of these practice parameters.
Journal ArticleDOI
The 3 major types of innate and adaptive cell-mediated effector immunity.
TL;DR: Based on emerging knowledge on the different effector T-cell and innate lymphoid cell (ILC) lineages, it is clear that the innate and adaptive immune systems converge into three major kinds of cell-mediated effector immunity, which are classified as type 1, type 2, and type 3 as discussed by the authors.
References
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Functions of natural killer cells
Eric Vivier,Elena Tomasello,Elena Tomasello,Myriam Baratin,Myriam Baratin,Thierry Walzer,Thierry Walzer,Sophie Ugolini,Sophie Ugolini +8 more
TL;DR: Although NK cells might appear to be redundant in several conditions of immune challenge in humans, NK cell manipulation seems to hold promise in efforts to improve hematopoietic and solid organ transplantation, promote antitumor immunotherapy and control inflammatory and autoimmune disorders.
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Innate or Adaptive Immunity? The Example of Natural Killer Cells
Eric Vivier,David H. Raulet,Alessandro Moretta,Michael A. Caligiuri,Laurence Zitvogel,Lewis L. Lanier,Wayne M. Yokoyama,Sophie Ugolini,Sophie Ugolini +8 more
TL;DR: NK cells are now recognized to express a repertoire of activating and inhibitory receptors that is calibrated to ensure self-tolerance while allowing efficacy against assaults such as viral infection and tumor development.
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NATURAL KILLER CELLS IN ANTIVIRAL DEFENSE: Function and Regulation by Innate Cytokines
TL;DR: A detailed picture is developing of particular innate cytokines activating NK cell responses and their consorted effects in providing unique endogenous milieus promoting downstream adaptive responses, most beneficial in defense against viral infections.
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Innate lymphoid cells--a proposal for uniform nomenclature.
Hergen Spits,David Artis,Marco Colonna,Andreas Diefenbach,James P. Di Santo,Gérard Eberl,Shigeo Koyasu,Richard M. Locksley,Andrew N.J. McKenzie,Reina E. Mebius,Fiona Powrie,Eric Vivier,Eric Vivier +12 more
TL;DR: It is proposed that ILCs should be categorized into three groups based on the cytokines that they can produce and the transcription factors that regulate their development and function.
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Human natural killer cells
TL;DR: There has been a substantial gain in understanding of what and how NK-cells "see," lending important insights into their functions and purpose in normal immune surveillance.