Natural phenanthrenes and their biological activity.
TL;DR: The present study furnishes an overview of the hydroxy or/and methoxy-substituted 9,10-dihydro/phenanthrene, methylated, prenylated and other monomeric derivatives, dimeric and trimeric phenanthrenes and their biological activities.
About: This article is published in Phytochemistry.The article was published on 2008-03-01. It has received 282 citations till now. The article focuses on the topics: Phenanthrenes.
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TL;DR: The applications of gold catalysed reactions in total synthesis during the years since the last article are reviewed and literature analysis is conducted to evaluate the progress in this field.
Abstract: In this critical review the applications of gold catalysed reactions in total synthesis during the years since our last article are reviewed. At the end of this article a literature analysis is conducted to evaluate the progress in this field.
617 citations
TL;DR: The bioactivity of several phytoalexins and phy toanticipins defending plants against fungal and bacterial aggressors and those with antibacterial activities against pathogens affecting humans such as Pseudomonas aeruginosa and Staphylococcus aureus involved in respiratory infections of cystic fibrosis patients are discussed.
Abstract: To protect themselves, plants accumulate an armoury of antimicrobial secondary metabolites. Some metabolites represent constitutive chemical barriers to microbial attack (phytoanticipins) and others inducible antimicrobials (phytoalexins). They are extensively studied as promising plant and human disease-controlling agents. This review discusses the bioactivity of several phytoalexins and phytoanticipins defending plants against fungal and bacterial aggressors and those with antibacterial activities against pathogens affecting humans such as Pseudomonas aeruginosa and Staphylococcus aureus involved in respiratory infections of cystic fibrosis patients. The utility of plant products as “antibiotic potentiators” and “virulence attenuators” is also described as well as some biotechnological applications in phytoprotection.
348 citations
Cites background from "Natural phenanthrenes and their bio..."
...Multiple classes of antibacterial products, including phenolic acids and polyphenols [46], phenanthrenes [47], flavonoids [48], terpenoids [49] have been described and the bioactivities of many more plant products and essential oils are reviewed elsewhere [44,50,51]....
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TL;DR: This review focuses on the distribution of stilbenes and 2-arylbenzofuran derivatives in the plant kingdom, the chemical structure of stILbenes in the Vitaceae family and their taxonomic implication.
288 citations
253 citations
TL;DR: It appears that synergism plays a role in antimicrobial activity of plant extracts and that the hope of isolating a single compound that can be used as a new agent to address antibiotic resistance has been frustrated.
201 citations
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TL;DR: Among the identified compounds, five were found to exhibit anti-platelet aggregation activity in vitro and the structure of a previously reported compound dendroflorin obtained from the plant was revised on the basis of spectroscopic analysis.
143 citations
TL;DR: Fifteen new stilbenoids including 11 phenylbenz ofurans, the stemofurans A-K, and four dihydrostilbenes, the stilbostemins A, C, E, and F were isolated and identified from a methanolic extract of Stemona collinsae roots.
Abstract: Fifteen new stilbenoids including 11 phenylbenzofurans, the stemofurans A−K (1−11), and four dihydrostilbenes, the stilbostemins A (15), C (17), E (19), and F (20), were isolated and identified from a methanolic extract of Stemona collinsae roots together with five known derivatives, the stilbenes pinosylvin (13) and 4‘-methylpinosylvin (14), the dihydrostilbenes, stilbostemins B (16) and D (18), and the dihydrophenanthrene racemosol (12) as well as (+)-sesamin, coniferyl alcohol, and stigmasterol. Bioautographic tests with Cladosporium herbarum displayed antifungal activity for stilbenoids of all four structural types. Ten derivatives were tested against five microfungi using the microdilution technique linked with digital image analysis of germ tubes.
133 citations
TL;DR: Two phenanthrenes were isolated from the aerial part of Dendrobium nobile Lindl and were found to be cytotoxic against A549, SK-OV-3, and HL-60 cell lines and antitumor activity on the life span of ICR mice intraperitoneally implanted with 1 x 10(6) cells of sarcoma 180.
Abstract: Two phenanthrenes were isolated from the aerial part of Dendrobium nobile Lindl. and their structures were identified to be 4,7-dihydroxy-2-methoxy-9,10-dihydrophenanthrene (1) and denbinobin (2), among which the former has been first isolated from this plant. These two compounds were found to be cytotoxic against A549 (human lung carcinoma), SK-OV-3 (human ovary adenocarcinoma), and HL-60 (human promyelocytic leukemia) cell lines. Compound 1 also showed antitumor activity on the life span of ICR mice intraperitoneally implanted with 1 x 10(6) cells of sarcoma 180.
130 citations
TL;DR: In this paper, three new bibenzyls and two dihydrophenanthrenes, which exhibit antimicrobial activity, were isolated from tubers of Bletilla striata.
112 citations
TL;DR: Two new phenanthrenes (4,9-dimethoxyphenanthrene-2,5-diol and 4,6-dimethyltoxymethylhexane-1,3,7-triol) and two new 9,10-dihydrophenanthreness (4methoxy-9, 10-dibenzyls and the triterpenoid friedelin were isolated and characterized from the hexane extract of the orchid Bulbophyllum vaginatum) were determined by spectroscopic analyses
94 citations