NEAT1 Long Noncoding RNA and Paraspeckle Bodies Modulate HIV-1 Posttranscriptional Expression
Citations
536 citations
Cites background from "NEAT1 Long Noncoding RNA and Parasp..."
...Indeed, a recent report observed that NEAT1 modulates HIV-I replication by affecting the nucleus-to-cytoplasm export of Rev-dependent instability element-containing HIV-I mRNAs (Zhang et al., 2013)....
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490 citations
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...Both of them are located in nuclear paraspeckles and constitute an important structure of paraspeckles [238]....
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439 citations
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...Accumulating evidences have further demonstrated that mutations and dysregulations of these lncRNAs are associated with the development and progression of various complex human diseases [21], such as prostate cancer [22, 23], colon cancer [24], lung cancer [25], Alzheimer’s diseases (AD) [26], cardiovascular diseases [27], leukemia [28], diabetes [29], AIDS [30] and neurodegeneration diseases [31]....
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...Considering the various functions of lncRNAs, it is no surprise to find that the mutations and dysregulations of lncRNAs are closely related to the development and progression of many kinds of human diseases [2, 16, 69, 82, 97–99], such as breast cancer [21, 100], prostate cancer [22, 23], hepatocellular cancer (HCC) [101], colon cancer [24], bladder cancer [34], thyroid cancer [102], lung cancer [25, 103], ovarian cancer [104], AD [26], diabetes [29, 105] and AIDS [30]....
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409 citations
Cites background from "NEAT1 Long Noncoding RNA and Parasp..."
...AlthoughNeat1 is essential for the integrity of the nuclear substructure, it has also been linked to the immune response after HIV-1 infection (Zhang et al., 2013) and might, therefore, be involved in the maintenance of immune regulatory circuits in MPP3-MPP4....
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403 citations
Cites background from "NEAT1 Long Noncoding RNA and Parasp..."
...Recently, the lncRNAs NEAT1 and MALAT1 were observed colocalizing with nuclear speckles containing the splicing factor SC35 [83]....
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...A previous study also linked HIV infection with upregulation of lncRNA NEAT1 [162]....
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...Both miR-101 and miR-217 negatively regulate metastasis associated with lung adenocarcinoma transcript 1 (MALAT1) in carcinoma cells [74], and miR-449a inhibits the expression of nuclear enriched abundant transcript 1 (NEAT1) lncRNA in lung cancer [75]....
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References
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"NEAT1 Long Noncoding RNA and Parasp..." refers background in this paper
...It is estimated that more than 70% of the human genome is transcribed into RNA (1, 2), while less than 2% of the total...
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4,911 citations
Additional excerpts
...tors in complex regulatory networks (13)....
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2,337 citations
2,312 citations
Additional excerpts
...number of protein-noncoding RNAs (ncRNAs) (5)....
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