Negative Regulation of FGFR (Fibroblast Growth Factor Receptor) Signaling.
Patrycja Szybowska,Michal Kostas,Michal Kostas,Jørgen Wesche,Jørgen Wesche,Ellen Margrethe Haugsten,Ellen Margrethe Haugsten,Antoni Wiedlocha +7 more
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In this paper, the authors review the numerous cellular mechanisms that regulate and turn off FGFR signaling, once the receptor is activated, including endocytosis and endocytic sorting, phosphatase activity, negative regulatory proteins and negative feedback phosphorylation events.Abstract:
FGFR (fibroblast growth factor receptor) signaling controls fundamental processes in embryonic, fetal and adult human life. The magnitude, duration, and location of FGFR signaling must be strictly controlled in order to induce the correct biological response. Uncontrolled receptor signaling has been shown to lead to a variety of diseases, such as skeletal disorders and cancer. Here we review the numerous cellular mechanisms that regulate and turn off FGFR signaling, once the receptor is activated. These mechanisms include endocytosis and endocytic sorting, phosphatase activity, negative regulatory proteins and negative feedback phosphorylation events. The mechanisms act together simultaneously or sequentially, controlling the same or different steps in FGFR signaling. Although more work is needed to fully understand the regulation of FGFR signaling, it is clear that the cells in our body have evolved an extensive repertoire of mechanisms that together keep FGFR signaling tightly controlled and prevent excess FGFR signaling.read more
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New developments in the biology of fibroblast growth factors.
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TL;DR: This review focuses on new developments in the FGF field since the last review in 2015, including the use of optogenetic tools, viral vectors, and inducible transgenes to experimentally modulate FGF signaling, the clinical use of small molecule FGFR inhibitors, and an expanded understanding of endocrine F GF signaling.
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Truncated FGFR2 is a clinically actionable oncogene in multiple cancers
Daniel Zingg,Jinhyuk Bhin,Julia Yemelyanenko,Sjors M. Kas,Frank Rolfs,Catrin Lutz,Jessica K. Lee,Sjoerd Klarenbeek,Ian M. Silverman,Stefano Annunziato,Chang S. Chan,Sander R. Piersma,Timo Eijkman,Madelon Badoux,Ewa Gogola,Bjorn Siteur,Justin Sprengers,Bim de Klein,Richard de Goeij-de Haas,Greg Riedlinger,Hua Ke,Russell Madison,Anne Paulien Drenth,Eline van der Burg,Eva Schut,Linda Henneman,Martine H. van Miltenburg,Natalie Proost,Hui-Ling Zhen,Ellen Wientjens,Roebi de Bruijn,Julian R. de Ruiter,Ute Boon,Renske de Korte-Grimmerink,Bastiaan van Gerwen,Luis Féliz,Ghassan K. Abou-Alfa,Jeffrey S. Ross,M. van de Ven,Sven Rottenberg,Edwin Cuppen,Anne Vaslin Chessex,Siraj M. Ali,Timothy Burn,Connie R. Jimenez,Shridar Ganesan,Lodewyk F. A. Wessels,Jos Jonkers +47 more
TL;DR: In this paper , the truncation of exon 18 (E18) of Fgfr2 was found to be a potent driver mutation for FGFR2-targeted therapies.
Journal ArticleDOI
Truncated FGFR2 is a clinically actionable oncogene in multiple cancers
Daniel Zingg,Jinhyuk Bhin,Julia Yemelyanenko,Sjors M. Kas,Frank Rolfs,Catrin Lutz,Jessica K. Lee,Sjoerd Klarenbeek,Ian M. Silverman,Stefano Annunziato,Chang S. Chan,Sander R. Piersma,Timo Eijkman,Madelon Badoux,Ewa Gogola,Bjorn Siteur,Justin Sprengers,Bim Klein,Richard Goeij-de Haas,Greg Riedlinger,Hua Ke,Russell Madison,Anne Paulien Drenth,E. Burg,Eva Schut,Linda Henneman,Martine H. van Miltenburg,Natalie Proost,Hui-Ling Zhen,Ellen Wientjens,Roebi de Bruijn,Julian R. de Ruiter,Ute Boon,R. Korte-Grimmerink,Bastiaan van Gerwen,Luis Féliz,Ghassan K. Abou-Alfa,Jeffrey S. Ross,M. W. C. M. Van De Ven,Sven Rottenberg,Edwin Cuppen,Anne Vaslin Chessex,Siraj M. Ali,Timothy Burn,Connie R. Jimenez,Shridar Ganesan,Lodewyk F. A. Wessels,Jos Jonkers +47 more
TL;DR: In this article , the truncation of exon 18 (E18) of Fgfr2 was found to be a potent driver mutation for FGFR2-targeted therapies.
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MiRNA 24-3p-rich exosomes functionalized DEGMA-modified hyaluronic acid hydrogels for corneal epithelial healing.
Xiaomin Sun,Wen-Guang Song,Li Zhao Teng,Yongrui Huang,Jian Liu,Yuehai Peng,Xiao Lu,Jin Yuan,Xuan Zhao,Qi Zhao,Ying Xu,Jingjie Shen,Xiaoyun Peng,Li Ren +13 more
TL;DR: In this paper , the authors explored ocu-microRNA 24-3p (miRNA 24 3p) that can promote rabbit corneal epithelial cells migration and cornea repair.
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Roles of the FGF-FGFR Signaling System in Cancer Development and Inflammation.
Antoni Wiedlocha,Antoni Wiedlocha,Ellen Margrethe Haugsten,Ellen Margrethe Haugsten,Malgorzata Zakrzewska +4 more
TL;DR: For multi-cellular organisms to organize tissues, their cells must communicate with each other as discussed by the authors, and for multicell cells to organize themselves, they need to communicate each other.
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