Network analysis of intermediary metabolism using linear optimization. I. Development of mathematical formalism.
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Cites background from "Network analysis of intermediary me..."
...…(i) the maximization of metabolite (Varma et al., 1993a) or ATP (Majewski and Domach, 1990; Ramakrishna et al., 2001) production; and (ii) the minimization of the Euclidean norm (i.e., sum of the fluxes) (Bonarius et al., 1996), nutrient uptake, or redox production (Savinell and Palsson, 1992)....
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...Other postulated objective functions include: (i) the maximization of metabolite (Varma et al., 1993a) or ATP (Majewski and Domach, 1990; Ramakrishna et al., 2001) production; and (ii) the minimization of the Euclidean norm (i.e., sum of the fluxes) (Bonarius et al., 1996), nutrient uptake, or redox production ( Savinell and Palsson, 1992 )....
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Cites background from "Network analysis of intermediary me..."
...This suggested that pyruvate dehydrogenase could be a rigid node, or may be related to a bottleneck in the import of NADH from cytoplasm into mitochondria (Paredes et al., 1998; Savinell and Palsson, 1992)....
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