Network analysis of intermediary metabolism using linear optimization. I. Development of mathematical formalism.
Citations
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Cites background or methods from "Network analysis of intermediary me..."
...This objective function was implemented by optimizing the exchange flux for uptake of external nutrients (Savinell and Palsson, 1992), succinate in this case....
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...It is also the first use of a Bayesian approach to identify potential metabolic functions....
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...Contact: srivasta@engr.uconn.edu Supplementary information: Additional files, code and a program for carrying out model discrimination are available at http://www.engr. uconn.edu/~srivasta/modisc.html....
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...In addition, instead of using a heuristic approach to choose the best objective function (Savinell and Palsson, 1992), a single value, the posterior probability share, is used....
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...…et al., 1993, 1999; Holms, 1996; Ibarra et al., 2002; Majewski and Domach, 1990; Mavrovouniotis et al., 1992; Raman et al., 2005; Reed et al., 2003; Sauer et al., 1996, 1998; Savinell and Palsson, 1992; Schilling et al., 2000, 2002; Schilling and Palsson, 2000; Vallino and Stephanopoulos, 2000)....
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97 citations
Cites background or methods from "Network analysis of intermediary me..."
...Therefore, structural approaches to analyse metabolic pathways have attracted ample interest (Reder, 1988; Mavrovouniotis et al., 1990a; Schuster and Schuster, 1991; Savinell and Palsson, 1992; Vallino and Stephanopoulos, 1993)....
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...An alternative method for calculating maximum efficiencies is by using linear optimisation techniques (Fell and Small, 1986; Savinell and Palsson, 1992)....
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...Therefore, structural approaches to analyse metabolic pathways have attracted ample interest (Reder, 1988; Mavrovouniotis et al., 1990a; Schuster and Schuster, 1991; Savinell and Palsson, 1992; Vallino and Stephanopoulos, 1993)....
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95 citations
94 citations
Cites methods from "Network analysis of intermediary me..."
...Previous investigations have similarly used minimal stoichiometric models to explore the effects of using a variety of objective functions on metabolic phenotype, the sensitivity of growth rate and other fluxes to perturbations, and the consistency between these in silico predictions and empirical measurements in a mammalian cell line [21, 22]....
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References
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