Network analysis of protein structures identifies functional residues.
Citations
479 citations
Cites methods from "Network analysis of protein structu..."
...including the Catalytic Site Atlas [78**], PDBFun [79], PDBSite and PDBSiteScan [80, 81], SuMo [82, 83], pvSOAR [84], SARIG [85], FEATURE [86, 87], RIGOR [88] and PatchFinder [89] (Table 2)....
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...Several more such databases and associated search algorithms exist, including the Catalytic Site Atlas [78**], PDBFun [79], PDBSite and PDBSiteScan [80, 81], SuMo [82, 83], pvSOAR [84], SARIG [85], FEATURE [86, 87], RIGOR [88] and PatchFinder [89] (Table 2)....
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389 citations
373 citations
Cites background from "Network analysis of protein structu..."
..., Theoretical Microscopic Titration Curves (THEMATICS) [35], binding site similarity [36], phage display libraries [37], and residue interaction graphs [38])....
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315 citations
Cites background from "Network analysis of protein structu..."
...…proven to be useful in a number of studies, such as protein folding (Vendruscolo et al, 2002), residue contribution to the protein–protein binding free energy in given complexes (del Sol and O’Meara, 2004) and prediction of functionally important residues in enzyme families (Amitai et al, 2004)....
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...Based on a large set of enzymes, Amitai et al (2004) have shown that active site residues tend to be highly central in the structure, suggesting that these positions are crucial for the transmission of information between the residues in the protein....
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308 citations
Cites background from "Network analysis of protein structu..."
...[35] aims to identify active site residues through network analysis of protein structures....
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References
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"Network analysis of protein structu..." refers background in this paper
...Frequently these networks include a small number of central nodes that are hubs through which many nodes can indirectly connect.(23) We sought to examine whether central nodes of protein residue interaction networks correspond to functional residues....
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