Network motifs in the transcriptional regulation network of Escherichia coli
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Cites background from "Network motifs in the transcription..."
...The statistical structure of regulatory networks has been studied recently by various authors [152, 184, 368]....
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...[284, 368] have presented a novel analysis that picks out recurrent motifs—small subgraphs—from complete networks....
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7,475 citations
Cites background from "Network motifs in the transcription..."
...However, the incoming degree distribution, which tells us how many different transcription factors interact with a given gene, is best approximated by an exponential, which indicates that most genes are regulated by one to three transcription factors...
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...When both regulators are positive, the feedforward loop can provide consistent activity that is relatively insensitive to transient changes in input (Mangan et al., 2003; Shen-Orr et al., 2002)....
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...Previous studies have shown that feedforwardloop architecture has been highly favored during the evolution of transcriptional regulatory networks in less complex eukaryotes (Lee et al., 2002; Ma et al., 2004; Milo et al., 2002; Resendis-Antonio et al., 2005; Shen-Orr et al., 2002)....
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...The simplest units of commonly used transcriptional regulatory network architecture, or network motifs, provide specific regulatory capacities such as positive and negative feedback loops to control the levels of their components (Lee et al., 2002; Milo et al., 2002; Shen-Orr et al., 2002)....
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...Autoregulation is thought to provide several advantages, including reduced response time to environmental stimuli and increased stability of gene expression (McAdams and Arkin, 1997; Rosenfeld et al., 2002; Shen-Orr et al., 2002; Thieffry et al., 1998)....
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4,080 citations
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