Neurobiology of the incubation of drug craving
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1,039 citations
Cites background from "Neurobiology of the incubation of d..."
...Craving is an exception because it can persist long into remission (109, 110)....
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864 citations
Cites background from "Neurobiology of the incubation of d..."
...Instead, the field needs to make greater use of drug self-administration and relapse assays, which are considered the best available animal models of addictio...
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787 citations
Cites background from "Neurobiology of the incubation of d..."
...increase in relapse vulnerability after a month or so of drug abstinence (Pickens et al., 2011)....
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...…fade over months of drug abstinence – if anything, sensitization grows for some time during abstinence (Paulson & Robinson, 1995), a phenomenon sometimes called ‘incubation of drug craving’, which is an increase in relapse vulnerability after a month or so of drug abstinence (Pickens et al., 2011)....
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429 citations
Cites background from "Neurobiology of the incubation of d..."
...The use of reinstatement and extinction procedures has led to the discovery of incubation of drug craving...
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399 citations
Cites background or result from "Neurobiology of the incubation of d..."
...Also included in the figure are a much smaller number of studies on incubation of drug craving (Pickens et al. 2011), a phenomenon originally demonstrated in studies using the reinstatement model (Grimm et al....
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...We do not provide, in this review, an update on mechanisms of incubation of drug craving because we covered this topic in two recent reviews (Marchant et al. 2013; Pickens et al. 2011)....
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References
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"Neurobiology of the incubation of d..." refers background in this paper
...ERK activation also mediates some of the physiological effects of both BDNF and GDNF [63], including those related to the effects of exogenous BDNF and GDNF administration on drug-related behaviors [64–67] (see below)....
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...Ghitza UE, et al. Role of BDNF and GDNF in drug reward and relapse: a review....
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...Finally, the findings that inhibition of ERK activity in VTA reverses the effect of exogenous administration of both BDNF and GDNF in VTA on incubation of cocaine craving suggest that local ERK activity contributes to the effects of these growth factors on incubation of cocaine craving (see Fig....
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...These studies indicate that signaling pathways in the VTA that are downstream of the neurotrophins BDNF and GDNF play an important role in the incubation of cocaine craving....
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...N IH -PA Author M anuscript N IH -PA Author M anuscript N IH -PA Author M anuscript Role of BDNF and GDNF in the VTA and NAc BDNF and GDNF are neurotrophic factors that are important for the survival and function of midbrain dopamine neurons [74–76]....
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1,711 citations
"Neurobiology of the incubation of d..." refers background in this paper
...These neurotrophic factors also play a significant role in synaptic plasticity during development as well plasticity events associated with learning and memory [63, 77]....
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