Journal ArticleDOI
Neurogenic plasticity of mesenchymal stem cell, an alluring cellular replacement for traumatic brain injury.
Soumya Pati,Sangu Muthuraju,Raisah Ab Hadi,Tee Jong Huat,Shailja Singh,Mirjana Maletic-Savatic,Jafri Malin Abdullah,Hasnan Jaafar +7 more
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TLDR
A comprehensive data on the important attributes of MSCs, such as neurotransdifferentiation, neuroprotection, axonal repair and plasticity, maintenance of blood-brain integrity, reduction of reactive oxygen species (ROS) and immunomodulation are presented.Abstract:
Traumatic brain injury (TBI) imposes horrendous neurophysiological alterations leading to most devastating forms of neuro-disability. Which includes impaired cognition, distorted locomotors activity and psychosomatic disability in both youths and adults. Emerging evidence from recent studies has identified mesenchymal stem cells (MSCs) as one of the promising category of stem cells having excellent neuroregenerative capability in TBI victims. Some of the clinical and animal studies reported that MSCs transplantation could cure neuronal damage as well as improve cognitive and locomotors behaviors in TBI. However, mechanism behind their broad spectrum neuroregenerative potential in TBI has not been reviewed yet. Therefore, in the present article, we present a comprehensive data on the important attributes of MSCs, such as neurotransdifferentiation, neuroprotection, axonal repair and plasticity, maintenance of blood-brain integrity, reduction of reactive oxygen species (ROS) and immunomodulation. We have reviewed in detail the crucial neurogenic capabilities of MSCs in vivo and provided consolidated knowledge regarding their cellular remodeling in TBI for future therapeutic implications.read more
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Journal ArticleDOI
Usage of Human Mesenchymal Stem Cells in Cell-based Therapy: Advantages and Disadvantages.
Hee Jung Kim,Jeong Soo Park +1 more
TL;DR: Although their limited cell proliferation potency protects them from malignant transformation after transplantation, senescence can alter various cell functions including proliferation, differentiation, and migration, that are essential for their therapeutic efficacy.
Journal ArticleDOI
Mesenchymal stem cell therapy for the treatment of traumatic brain injury: progress and prospects.
TL;DR: In this article, a review of mesenchymal stem cells (MSC) after Traumatic Brain Injury (TBI) and its future direction is presented. But, MSC therapy has a few drawbacks including tumor formation, which can be avoided by the use of MSC-derived exosomes.
Journal ArticleDOI
Plasmodium Merozoite TRAP Family Protein Is Essential for Vacuole Membrane Disruption and Gamete Egress from Erythrocytes.
Daniel Y. Bargieri,Daniel Y. Bargieri,Sabine Thiberge,Chwen L. Tay,Alison F. Carey,Alison F. Carey,Alice Rantz,Florian Hischen,Audrey Lorthiois,Ursula Straschil,Pallavi Singh,Shailja Singh,Tony Triglia,Takafumi Tsuboi,Alan F. Cowman,Alan F. Cowman,Chetan E. Chitnis,Pietro Alano,Jake Baum,Gabriele Pradel,Catherine Lavazec,Robert Ménard +21 more
TL;DR: Surface-associated TRAP (thrombospondin-related anonymous protein) family proteins are conserved across the phylum of apicomplexan parasites, indicating that motor-binding TRAP family members function not just in parasite motility and cell invasion but also in membrane disruption and cell egress.
Journal ArticleDOI
Protective effect of human umbilical cord mesenchymal stem cell exosomes on preserving the morphology and angiogenesis of placenta in rats with preeclampsia.
TL;DR: In this article, the effect of exosomes on placental tissue and angiogenesis in rats with preeclampsia (PE) was investigated using flow cytometry and immunohistochemistry.
Journal ArticleDOI
Conditioned Medium of Bone Marrow-Derived Mesenchymal Stromal Cells as a Therapeutic Approach to Neuropathic Pain: A Preclinical Evaluation
Kelly Barbosa Gama,Kelly Barbosa Gama,Dourivaldo Silva Santos,Afrânio Ferreira Evangelista,Daniela Nascimento Silva,Daniela Nascimento Silva,Adriano Costa de Alcântara,Ricardo Ribeiro dos Santos,Ricardo Ribeiro dos Santos,Milena Botelho Pereira Soares,Milena Botelho Pereira Soares,Milena Botelho Pereira Soares,Cristiane Flora Villarreal,Cristiane Flora Villarreal +13 more
TL;DR: The CM produces a powerful and long-lasting antinociceptive effect on neuropathic pain, which is related with modulatory properties on peripheral and central levels of cytokines involved with the maintenance of this syndrome.