Journal ArticleDOI
Neurological mechanisms of green tea polyphenols in Alzheimer's and Parkinson's diseases
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TLDR
Green tea polyphenols are now being considered as therapeutic agents in well controlled epidemiological studies, aimed to alter brain aging processes and to serve as possible neuroprotective agents in progressive neurodegenerative disorders such as Parkinson's and Alzheimer's diseases.Abstract:
Tea consumption is varying its status from a mere ancient beverage and a lifestyle habit, to a nutrient endowed with possible prospective neurobiological-pharmacological actions beneficial to human health. Accumulating evidence suggest that oxidative stress resulting in reactive oxygen species generation and inflammation play a pivotal role in neurodegenerative diseases, supporting the implementation of radical scavengers, transition metal (e.g., iron and copper) chelators, and nonvitamin natural antioxidant polyphenols in the clinic. These observations are in line with the current view that polyphenolic dietary supplementation may have an impact on cognitive deficits in individuals of advanced age. As a consequence, green tea polyphenols are now being considered as therapeutic agents in well controlled epidemiological studies, aimed to alter brain aging processes and to serve as possible neuroprotective agents in progressive neurodegenerative disorders such as Parkinson's and Alzheimer's diseases. In particular, literature on the putative novel neuroprotective mechanism of the major green tea polyphenol, (-)-epigallocatechin-3-gallate, are examined and discussed in this review.read more
Citations
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Beneficial Effects of Green Tea—A Review
TL;DR: Although all the evidence from research on green tea is very promising, future studies are necessary to fully understand its contributions to human health, and advise its regular consumption in Western diets, in which green tea consumption is nowadays limited and sporadic.
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Inhibition of amyloid fibril formation by polyphenols: structural similarity and aromatic interactions as a common inhibition mechanism.
TL;DR: This work suggests an additional mechanism of action assuming structural constraints and specific aromatic interactions, which direct polyphenol inhibitors to the amyloidogenic core, which is highly relevant for future de novo inhibitors‘ design as therapeutic agents for the treatment of amyloids‐associated diseases.
Journal ArticleDOI
Beneficial effects of green tea: A literature review
TL;DR: Long-term consumption of tea catechins could be beneficial against high-fat diet-induced obesity and type II diabetes and could reduce the risk of coronary disease.
Journal ArticleDOI
Emerging role of polyphenolic compounds in the treatment of neurodegenerative diseases: A review of their intracellular targets
TL;DR: Increasing number of studies demonstrated the efficacy of polyphenolic antioxidants from fruits and vegetables to reduce or to block neuronal death occurring in the pathophysiology of these disorders, and revealed that other mechanisms than the antioxidant activities could be involved in the neuroprotective effect of these phenolic compounds.
Journal ArticleDOI
Herbal extracts and phytochemicals: plant secondary metabolites and the enhancement of human brain function.
TL;DR: This review assesses the current evidence for the efficacy of a range of readily available plant-based extracts and chemicals that may improve brain function and which have attracted sufficient research in this regard to reach a conclusion as to their potential effectiveness as nootropics.
References
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Journal ArticleDOI
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