Neuromuscular transmission in new‐born rats
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TLDR
End‐plate potentials (e.p.s) were recorded intracellularly from the isolated phrenic/diaphragm preparation of the rat during the first few weeks of life.Abstract:
1. End-plate potentials (e.p.p.s) were recorded intracellularly from the isolated phrenic/diaphragm preparation of the rat during the first few weeks of life.2. Most e.p.p.s at birth were complex and resulted from the summation of two to four units, which could be separated by their different latencies and thresholds to stimulation of the phrenic nerve.3. The e.p.p.s became simpler during the second week of the rats' life, and by 16-18 days old the e.p.p.s consisted of single units, and resembled the e.p.p.s of adult rat muscle.4. It is proposed that the units of the e.p.p. resulted from the stimulation of separate nerve axons and that all but one of the synapses on each muscle fibre were lost during the second week of life.read more
Citations
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References
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Journal ArticleDOI
An investigation of spontaneous activity at the neuromuscular junction of the rat.
TL;DR: The occurrence of spontaneous subthreshold activity at the neuromuscular junction of the albino rat has been observed and the characteristics of this activity have been investigated, both in isolated tissues and, to a less extent, in vivo.
Journal ArticleDOI
A study of foetal and new-born rat muscle fibres.
J. Diamond,Ricardo Miledi +1 more
Journal ArticleDOI
Cell degeneration in the larval ventral horn of Xenopus laevis (Daudin).
TL;DR: The aim has been to draw up a cell balance-sheet during development based both on counts of numbers of ventral horn neuroblasts throughout their differentiation, and also of the number of degenerating cells among them at each stage.
Journal ArticleDOI
Development of the myoneural junction in the rat.
TL;DR: Observations are interpreted to indicate that functional differentiation of the myoneural synapse results from induction by the motor axon and that the association of the sarcoplasmic reticulum with the postjunctional sarcoplasms in adult extraocular muscles is related to modified fibre physiology.
Journal ArticleDOI
A study of postnatal growth of skeletal muscle in the rat
TL;DR: From each of five litters of Sprague‐Dawley rats, littermates were sacrificed at 1, 3, 6, 12 and 24 weeks of age and the total cross sectional area, number of fibers contained within it; the size, in terms of cross‐sectional area, of fibers; and the ratio of muscle to connective tissue were calculated.
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