Neuronal replacement: Concepts, achievements, and call for caution
Magdalena Götz,Riccardo Bocchi +1 more
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TLDR
In this paper, the authors proposed a molecular program for neuronal subtype specification, allowing engineering of more precise neuronal subtypes and disentangling subtype diversity from dynamic transcriptional states.About:
This article is published in Current Opinion in Neurobiology.The article was published on 2021-05-10 and is currently open access. It has received 12 citations till now. The article focuses on the topics: Transplantation.read more
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Brain Plasticity in Humans and Model Systems: Advances, Challenges, and Future Directions
TL;DR: A review of recent studies focused on brain plasticity across the lifespan and in different species can be found in this paper, where the authors discuss their recent progress aimed to identify corresponding ages across species, and how this information can be used to map temporal variation in plasticity from model systems to humans.
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In vivo glia‐to‐neuron conversion: pitfalls and solutions
Lei-Lei Wang,Chun Li Zhang +1 more
TL;DR: In vivo glia‐to‐neuron (GtN) conversion emerges as a potential solution for regeneration‐based therapeutics that takes advantage of the regenerative ability of resident glial cells to produce new neurons through cell fate reprogramming.
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Ectopic insert-dependent neuronal expression of GFAP promoter-driven AAV constructs in adult mouse retina
TL;DR: Strong insert-dependent effects on AAV-based GFAP mini promoter specificity that preclude its use in inferring cell lineage relationships when studying glia-to-neuron conversion in retina are demonstrated.
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In vivo astrocyte-to-neuron reprogramming for central nervous system regeneration: a narrative review
Feng Gao,Jianjun Li,Zuliyaer Talifu,Jia-Yi Liu,Yunzhu Pan,Han Ke,Chunyan Zhang,Xinjing Xu,Yan Yu,Liangjie Du +9 more
TL;DR: Progress in reprogramming astrocytes into neurons in vivo in animal models of spinal cord injury, brain injury, Huntington's disease, Parkinson’s disease, Alzheimer’S disease, and other neurodegenerative conditions is summarized.
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Excessive local host-graft connectivity in aging and amyloid-loaded brain
Maria Fernanda Martinez-Reza,Manja Thorwirth,Yvette Zarb,Karl-Klaus Conzelmann,Stefanie M. Hauck,Sofia Grade,Magdalena Götz +6 more
TL;DR: State-of-the-art deep proteome analysis using mass spectrometry highlights complement system activation as a common denominator of environments promoting excessive local input connectivity in both amyloid-loaded and aged environments.
References
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Ageing and parkinson's disease: substantia nigra regional selectivity
Julian Fearnley,Andrew J. Lees +1 more
TL;DR: It is suggested that age-related attrition of pigmented nigral cells is not an important factor in the pathogenesis of Parkinson's disease and the regional selectivity of PD is relatively specific.
Journal ArticleDOI
Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq
Amit Zeisel,Ana B. Muñoz-Manchado,Simone Codeluppi,Peter Lönnerberg,Gioele La Manno,Anna Juréus,Sueli Marques,Hermany Munguba,Liqun He,Christer Betsholtz,Christer Betsholtz,Charlotte Rolny,Gonçalo Castelo-Branco,Jens Hjerling-Leffler,Sten Linnarsson +14 more
TL;DR: Large-scale single-cell RNA sequencing is used to classify cells in the mouse somatosensory cortex and hippocampal CA1 region and found 47 molecularly distinct subclasses, comprising all known major cell types in the cortex.
Journal ArticleDOI
Molecular Architecture of the Mouse Nervous System.
Amit Zeisel,Hannah Hochgerner,Peter Lönnerberg,Anna Johnsson,Fatima Memic,Job van der Zwan,Martin Häring,Emelie Braun,Lars E. Borm,Gioele La Manno,Simone Codeluppi,Alessandro Furlan,Kawai Lee,Nathan G. Skene,Kenneth D. Harris,Jens Hjerling-Leffler,Ernest Arenas,Patrik Ernfors,Ulrika Marklund,Sten Linnarsson +19 more
TL;DR: RNA sequencing of half a million single cells was used to create a detailed census of cell types in the mouse nervous system and mapped cell types spatially and derived a hierarchical, data-driven taxonomy.
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Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease
Sonja Kriks,Jae-Won Shim,Jinghua Piao,Yosif Ganat,Dustin R. Wakeman,Zhi-Zhong Xie,Luis Carrillo-Reid,Gordon Auyeung,Chris Antonacci,Amanda Buch,Lichuan Yang,M. Flint Beal,D. James Surmeier,Jeffrey H. Kordower,Viviane Tabar,Lorenz Studer +15 more
TL;DR: A novel floor-plate-based strategy for the derivation of human DA neurons that efficiently engraft in vivo is presented, suggesting that past failures were due to incomplete specification rather than a specific vulnerability of the cells.
Journal ArticleDOI
Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytes
Kevin D. Foust,Emily Nurre,Emily Nurre,Chrystal L. Montgomery,Anna Hernandez,Curtis M Chan,Brian K. Kaspar,Brian K. Kaspar +7 more
TL;DR: It is shown that adeno-associated virus (AAV) 9 injected intravenously bypasses the BBB and efficiently targets cells of the central nervous system (CNS) and may enable the development of gene therapies for a range of neurodegenerative diseases.
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Neuronal replacement therapy: previous achievements and challenges ahead.
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