Neuropathological evidence of body-first vs. brain-first Lewy body disease.
Per Borghammer,Jacob Horsager,Katrine B. Andersen,Nathalie Van Den Berge,Anna Raunio,Shigeo Murayama,Laura Parkkinen,Liisa Myllykangas +7 more
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TLDR
In this paper, the authors explore the possibility that clinical body-first and brain-first subtypes are equivalent to the caudo-rostral and amygdala-centered patterns of Lewy pathology seen at post mortem.About:
This article is published in Neurobiology of Disease.The article was published on 2021-11-08 and is currently open access. It has received 48 citations till now. The article focuses on the topics: Lewy body & Dementia with Lewy bodies.read more
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Clinical and imaging evidence of brain-first and body-first Parkinson's disease
TL;DR: In this article , the authors used REM-sleep behavior disorder (RBD) as a clinical identifier to distinguish between body-first and brain-first PD patients, and explored the literature to evaluate clinical and imaging differences between these proposed subtypes.
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The Impact of Type 2 Diabetes in Parkinson's Disease
Dilan Athauda,Dilan Athauda +1 more
TL;DR: In this article , the influence of Type 2 diabetes on aspects of disease progression in Parkinson's was investigated, and the effects of comorbid T2DM on PD progression and quality of life by comparing symptom severity scores assessing a range of motor and nonmotor symptoms.
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PET Imaging of Cholinergic Neurotransmission in Neurodegenerative Disorders.
Solveig Tiepolt,Philipp T. Meyer,Marianne Patt,Winnie Deuther-Conrad,Swen Hesse,Henryk Barthel,Osama Sabri +6 more
TL;DR: Taken together, PET of distinct components of cholinergic neurotransmission is of great interest for diagnosis, disease monitoring, and therapy monitoring and to gain insight into the pathophysiology of different neurodegenerative disorders.
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Passive Immunization in Alpha-Synuclein Preclinical Animal Models
TL;DR: New research strategies to increase translational outcome in patient studies are proposed by using antibodies against immature conformations of pathogenic αsyn (monomers, post-translationally modified monomers, oligomers and protofibrils) and by focusing treatment on body-first synucleinopathies where damage in the brain is still limited and effective immunization could potentially stop disease progression by blocking the spread of pathogen αsyn from peripheral organs to the brain.
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Impact of aging on animal models of Parkinson's disease
Ida H. Klæstrup,Mie Kristine Just,Karina Lassen Holm,Aage Kristian Olsen Alstrup,Marina Romero-Ramos,Per Borghammer,Nathalie Van Den Berge +6 more
TL;DR: Overall, current findings indicate that the use of aged animals may be required to account for age-related interactions in PD pathophysiology, and a model that better represents clinical disease within the elderly would be more beneficial in the long run, as it will increase translational value and minimize the risk of therapies failing during clinical studies.
References
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Journal ArticleDOI
Staging of brain pathology related to sporadic Parkinson’s disease
TL;DR: This study traces the course of the pathology in incidental and symptomatic Parkinson cases proposing a staging procedure based upon the readily recognizable topographical extent of the lesions.
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Alpha-synuclein in Lewy bodies.
Maria Grazia Spillantini,Marie L. Schmidt,Virginia M.-Y. Lee,John Q. Trojanowski,Ross Jakes,Michel Goedert +5 more
TL;DR: Strong staining of Lewy bodies from idiopathic Parkinson's disease with antibodies for α-synuclein, a presynaptic protein of unknown function which is mutated in some familial cases of the disease, indicates that the LewY bodies from these two diseases may have identical compositions.
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Diagnosis and management of dementia with Lewy bodies: Third report of the DLB Consortium
Ian G. McKeith,Ian G. McKeith,Dennis W. Dickson,James Lowe,Murat Emre,John T. O'Brien,Howard Feldman,Jeffrey L. Cummings,John E. Duda,Carol F. Lippa,Elaine K. Perry,Dag Aarsland,Hiroyuki Arai,Clive Ballard,B. F. Boeve,David J. Burn,Durval C. Costa,T. Del Ser,Bruno Dubois,Douglas Galasko,Serge Gauthier,Christopher G. Goetz,Estrella Gómez-Tortosa,Glenda M. Halliday,L. A. Hansen,John Hardy,Takeshi Iwatsubo,Raj N. Kalaria,Daniel I. Kaufer,Rose Anne Kenny,Amos D. Korczyn,Kenji Kosaka,Virginia M.-Y. Lee,Andrew J. Lees,Irene Litvan,Elisabet Londos,Oscar L. Lopez,Satoshi Minoshima,Yoshikuni Mizuno,José Antonio Molina,Elizabeta B. Mukaetova-Ladinska,Florence Pasquier,Robert H. Perry,Jörg B. Schulz,John Q. Trojanowski,Masahito Yamada +45 more
TL;DR: The dementia with Lewy bodies (DLB) Consortium has revised criteria for the clinical and pathologic diagnosis of DLB incorporating new information about the core clinical features and suggesting improved methods to assess them as mentioned in this paper.
Journal ArticleDOI
Diagnosis and management of dementia with Lewy bodies Fourth consensus report of the DLB Consortium
Ian G. McKeith,Bradley F. Boeve,Dennis W. Dickson,Glenda M. Halliday,John-Paul Taylor,Daniel Weintraub,Dag Aarsland,Dag Aarsland,James E. Galvin,Johannes Attems,Johannes Attems,Clive Ballard,Clive Ballard,Ashley Bayston,Ashley Bayston,Thomas G. Beach,Thomas G. Beach,Frédéric Blanc,Nicolaas Bohnen,Nicolaas Bohnen,Nicolaas Bohnen,Laura Bonanni,Laura Bonanni,Jose Bras,Jose Bras,Patrik Brundin,Patrik Brundin,David J. Burn,David J. Burn,Alice Chen-Plotkin,John E. Duda,Omar M. A. El-Agnaf,Howard Feldman,Tanis J. Ferman,Dominic Ffytche,Hiroshige Fujishiro,Douglas Galasko,Jennifer G. Goldman,Stephen N. Gomperts,Neill R. Graff-Radford,Lawrence S. Honig,Lawrence S. Honig,Alex Iranzo,Alex Iranzo,Alex Iranzo,Kejal Kantarci,Daniel I. Kaufer,Walter Kukull,Virginia M.Y. Lee,James B. Leverenz,James B. Leverenz,Simon J.G. Lewis,Carol F. Lippa,Carol F. Lippa,Angela Lunde,M Masellis,M Masellis,M Masellis,Eliezer Masliah,Pamela J. McLean,Brit Mollenhauer,Brit Mollenhauer,Thomas J. Montine,Thomas J. Montine,Emilio Moreno,Emilio Moreno,Emilio Moreno,Etsuro Mori,Etsuro Mori,Etsuro Mori,Melissa E. Murray,John T. O'Brien,John T. O'Brien,Sotoshi Orimo,Sotoshi Orimo,Ronald B. Postuma,Ronald B. Postuma,Shankar Ramaswamy,Shankar Ramaswamy,Owen A. Ross,David P. Salmon,David P. Salmon,Andrew B. Singleton,Andrew B. Singleton,Angela Taylor,Angela Taylor,Alan Thomas,Pietro Tiraboschi,Jon B. Toledo,John Q. Trojanowski,Debby W. Tsuang,Zuzana Walker,Zuzana Walker,Masahito Yamada,Masahito Yamada,Kenji Kosaka +95 more
TL;DR: The Dementia with Lewy Bodies (DLB) Consortium has refined its recommendations about the clinical and pathologic diagnosis of DLB, updating the previous report, which has been in widespread use for the last decade.
Journal ArticleDOI
Idiopathic Parkinson's disease: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen.
TL;DR: The here hypothesized mechanism offers one possible explanation for the sequential and apparently uninterrupted manner in which vulnerable brain regions, subcortical grays and cortical areas become involved in idiopathic Parkinson's disease.