Neuropeptide S is a stimulatory anxiolytic agent: a behavioural study in mice
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Additional excerpts
...(Xu et al., 2004; Vitale et al., 2008; Rizzi et al., 2008)....
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117 citations
Cites background from "Neuropeptide S is a stimulatory anx..."
...Thus, it reduced anxiety-related behavior in several relevant tests for non-social anxiety in both mice (Jüngling et al., 2008; Leonard et al., 2008; Rizzi et al., 2008; Xu et al., 2004) and rats (Slattery et al., 2008; Vitale et al., 2008; Wegener et al., 2011), mostly accompanied by an increase…...
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...Thus, it reduced anxiety-related behavior in several relevant tests for non-social anxiety in both mice (Jüngling et al., 2008; Leonard et al., 2008; Rizzi et al., 2008; Xu et al., 2004) and rats (Slattery et al....
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110 citations
109 citations
Cites background from "Neuropeptide S is a stimulatory anx..."
...NPS and its cognate receptor, NPSR, modulate multiple brain functions, including sleep, arousal, and emotional processing (Xu et al, 2004; Okamura and Reinscheid, 2007; Rizzi et al, 2008; Leonard et al, 2008)....
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...Pre-training and pre-retrieval administrations of NPS resulted in shorter IA latencies than vehicle treatment, most likely owing to the acute anxiolytic effects of NPS (Xu et al, 2004; Rizzi et al, 2008; Leonard et al, 2008; Jüngling et al, 2008)....
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References
5,391 citations
"Neuropeptide S is a stimulatory anx..." refers methods in this paper
...The EPM assay was carried out essentially as previously described by Pellow et al. (1985)....
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562 citations
"Neuropeptide S is a stimulatory anx..." refers methods in this paper
...Data analysis The pharmacological terminology adopted in this paper is consistent with IUPHAR recommendations (Neubig et al., 2003)....
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...The pharmacological terminology adopted in this paper is consistent with IUPHAR recommendations (Neubig et al., 2003)....
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474 citations
"Neuropeptide S is a stimulatory anx..." refers background or methods or result in this paper
...…of different centrally mediated behaviours, including locomotor activity (LA) (Xu et al., 2004; Roth et al., 2006; Smith et al., 2006), wakefulness (Xu et al., 2004), anxiety (Xu et al., 2004; Leonard et al., 2007), food intake (Beck et al., 2005; Ciccocioppo et al., 2006; Smith et al., 2006;…...
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...Similar results in terms of degree of stimulation, NPS potency, onset and duration of action were previously reported both in mice (Xu et al., 2004) and in rats (Smith et al., 2006)....
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...NPS and its receptor are expressed in various tissues with the highest levels found in the brain, thyroid, salivary and mammary glands (Xu et al., 2004)....
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...These findings parallel the results obtained by Xu et al. (2004) in rats in electroencephalographic studies, where NPS given i.c.v. in the same dose range (that is, 0.1 and 1 nmol) increases the amount of wakefulness and decreases SWS1, SWS2 and REM sleep....
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...Following formal pairing with NPS, the GPR154 receptor was named the NPS receptor (Xu et al., 2004)....
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456 citations
"Neuropeptide S is a stimulatory anx..." refers background in this paper
...With respect to biological activity, genetic studies indicate a possible peripheral involvement of the NPS/NPS receptor system in chronic inflammatory conditions of barrier organs, such as asthma (Laitinen et al., 2004) and ulcerative colitis/ Crohn’s disease (D’Amato et al., 2007)....
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390 citations
"Neuropeptide S is a stimulatory anx..." refers methods in this paper
...…(2 ml per mouse) were given under light (just sufficient to produce a loss of the righting reflex) ether anaesthesia into the left ventricle according to the procedure described by Laursen and Belknap (1986) and routinely adopted in our laboratory (Rizzi et al., 2002; Gavioli et al., 2003)....
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