Journal ArticleDOI
Neuroprotective effects of oleuropein: Recent developments and contemporary research.
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TLDR
In this article, the chemistry, biosynthesis, and metabolism of oleuropein along with an updated vision of its neuroprotective role in counteracting the acute and chronic neurodegenerative and neuropsychiatric disorders.Abstract:
Neurological disorders are increasing at a faster pace due to oxidative stress, protein aggregation, excitotoxicity, and neuroinflammation. It is reported that the Mediterranean diet including olives as a major dietary component prevents and ameliorates neurological anomalies. Oleuropein is the major bioactive component in different parts of the Olive (Olea europaea L.) tree. Several mechanisms have been reported for the neuroprotective role of oleuropein including induction of apoptosis and autophagy, enhancing the antioxidant pool of the cerebral region, decreasing the unnecessary release of proinflammatory cytokines and chemokines by deactivating the microglia cells and astrocytes thus preventing the occurrence of neuroinflammation. Regular intake of oleuropein seems to be correlated with decreased risks of neural disorders including Alzheimer's, Parkinson's, strokes, depression, anxiety, epilepsy, and others. This review majorly discusses the chemistry, biosynthesis, and metabolism of oleuropein along with an updated vision of its neuroprotective role in counteracting the acute and chronic neurodegenerative and neuropsychiatric disorders. Moreover, mechanisms by which oleuropein may prevent neurodegeneration are reviewed. PRACTICAL APPLICATION: Neurological disorders are negatively affecting the health and life quality of individuals around the globe. Although various medicinal solutions are available to tackle such ailments, none has proven to fully cure and being deprived of side effects. In this respect, the prevention of such disorders using natural remedies may be an effective strategy to overcome the incidence of the increasing cases. Furthermore, the natural compounds provide a safer alternative to pharmaceutical drugs. Hence, oleuropein from olive tree products is found to be efficacious against neurological disorders. This review provides an updated insight on the positive effects of oleuropein against neurodegenerative and neuropsychiatric disorders. The diet practitioners and nutraceutical companies may benefit from the provided information to design and develop strategies to improve the mental health of suffering individuals.read more
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Journal ArticleDOI
Therapeutic Properties and Use of Extra Virgin Olive Oil in Clinical Nutrition: A Narrative Review and Literature Update
A Jiménez-Sánchez,Antonio Martínez-Ortega,Pablo Remón-Ruiz,A. Piñar-Gutiérrez,José Luis Pereira-Cunill,Pedro Pablo García-Luna +5 more
TL;DR: Current evidence supports the use of whole EVOO in diet therapy and the supplementation of its minor components to improve cardiovascular health, lipoprotein metabolism, and diabetes mellitus in clinical nutrition.
Journal ArticleDOI
Sensitive Detection of Hydroxytyrosol in Extra Virgin Olive Oils with a Novel Biosensor Based on Single-Walled Carbon Nanotubes and Tyrosinase
TL;DR: In this article , a new biosensor based on a screen-printed electrode modified with single-layer carbon nanotubes and tyrosinase (SPE-SWCNT-Ty) was used for quantitative determination of hydroxytyrosol in commercial extra virgin olive oils of different origins and varieties.
Journal ArticleDOI
Neuroprotective Panel of Olive Polyphenols: Mechanisms of Action, Anti-Demyelination, and Anti-Stroke Properties
TL;DR: In this article , the authors provided an updated version of the beneficial properties and mechanisms of action of olive polyphenols against demyelination in the prevention/mitigation of multiple sclerosis, the most common non-traumatic neurological cause of impairment in younger adults, and against cerebral insult with increasing incidence.
Journal ArticleDOI
The Multiple Sclerosis Modulatory Potential of Natural Multi-Targeting Antioxidants
TL;DR: Antioxidant compounds with specific characteristics are expected to affect positively some aspects of the disease, and their potential may render them as effective candidates for neurological impairment reduction in combination with the MS treatment regimen as mentioned in this paper .
Journal ArticleDOI
The Double-Edged Sword of Oleuropein in Ovarian Cancer Cells: From Antioxidant Functions to Cytotoxic Effects
Stefania Scicchitano,Eleonora Vecchio,Anna Martina Battaglia,Manuela Oliverio,Monica Nardi,Antonio Procopio,Francesco Costanzo,Flavia Biamonte,Maria Concetta Faniello +8 more
TL;DR: In this paper , the activity of oleuropein in an in vitro model of ovarian (OCCs) and breast cancer cells (BCCs) was investigated, and cell viability and cell death were analyzed.
References
More filters
Journal ArticleDOI
Neurotoxic reactive astrocytes are induced by activated microglia
Shane A. Liddelow,Kevin A. Guttenplan,Laura E. Clarke,Frederick C. Bennett,Christopher J. Bohlen,Lucas Schirmer,Mariko L. Bennett,Alexandra E. Münch,Won-Suk Chung,Todd C. Peterson,Daniel K. Wilton,Arnaud Frouin,Brooke A. Napier,Nikhil Panicker,Manoj Kumar,Marion S. Buckwalter,David H. Rowitch,Valina L. Dawson,Ted M. Dawson,Beth Stevens,Ben A. Barres +20 more
TL;DR: It is shown that activated microglia induce A1 astrocytes by secreting Il-1α, TNF and C1q, and that these cytokines together are necessary and sufficient to induce A2 astroCytes, which are abundant in various human neurodegenerative diseases.
Journal ArticleDOI
ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology.
Ingrid E. Scheffer,Samuel F. Berkovic,Giuseppe Capovilla,Mary B. Connolly,Jacqueline A. French,Laura Maria de Figueiredo Ferreira Guilhoto,Edouard Hirsch,Satish Jain,Gary W. Mathern,Solomon L. Moshé,Douglas R. Nordli,Emilio Perucca,Torbjörn Tomson,Samuel Wiebe,Yuehua Zhang,Sameer M. Zuberi,Sameer M. Zuberi +16 more
TL;DR: The International League Against Epilepsy (ILAE) Classification of the Epilepsies has been updated to reflect our gain in understanding of the epilepsies and their underlying mechanisms following the major scientific advances that have taken place since the last ratified classification in 1989 as mentioned in this paper.
Journal ArticleDOI
Depression and Quality of Life in Older Persons: A Review
TL;DR: A significant association between severity of depression and poorer QOL in older persons was found, and the association was found to be stable over time, regardless of which assessment instruments for QOL were applied.
Journal ArticleDOI
The role of inflammation in depression: from evolutionary imperative to modern treatment target
TL;DR: Current understanding of the mechanisms by which the innate and adaptive immune systems interact with neurotransmitters and neurocircuits to influence the risk for depression are detailed.
Journal ArticleDOI
State of play in amyotrophic lateral sclerosis genetics.
TL;DR: Current literature of the major genes underlying ALS, SOD1, TARDBP, FUS, OPTN, VCP, UBQLN2, C9ORF72 and PFN1 are summarized and how each new genetic discovery is broadening the phenotype associated with the clinical entity the authors know as ALS is outlined.