Journal ArticleDOI
Neuroprotective effects of probiotics bacteria on animal model of Parkinson’s disease induced by 6-hydroxydopamine: A behavioral, biochemical, and histological study
Esmail Alipour Nosrani,Omid Reza Tamtaji,Zahra Alibolandi,Parichehr Sarkar,Mohsen Ghazanfari,Abolfazl Azami Tameh,Mohsen Taghizadeh,Zarrin Banikazemi,Razie Hadavi,Mojtaba Naderi Taheri +9 more
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TLDR
It was shown that a mixture of probiotics containing Lactobacillus acidophilus, Bifidobacterium bifidum, LactObacillus reuteri, and LactOBacillus fermentum could improve rotational behavior, cognitive function, lipid peroxidation, and neuronal damage in the group received probiotic supplementation compared to the other groups.Abstract:
Parkinson’s disease (PD) is an age-associated, progressive, and common neurodegenerative disorder. It is characterized by dopaminergic neuron degeneration in the substantia nigra pars compacta. The...read more
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The Gut–Brain Axis and Its Relation to Parkinson’s Disease: A Review
Emily Klann,Upuli Anuradha Dissanayake,Anjela Gurrala,Matthew J. Farrer,Aparna Wagle Shukla,Adolfo Ramirez-Zamora,Volker Mai,Vinata Vedam-Mai +7 more
TL;DR: The role of α-synuclein in non-motor disease pathology, proposed pathways constituting the connection between the gut microbiome and the brain, existing evidence related to pre- and probiotic interventions, and the potential opportunity for the development of novel preventative measures and therapeutic options that could target the microbiome–gut–brain axis in the context of Parkinson’s disease are discussed.
Journal ArticleDOI
Interplay of gut microbiota and oxidative stress: Perspective on neurodegeneration and neuroprotection
TL;DR: In this paper , Gut-brain axis act as a vital pathway of communication and physiological regulation, and the potential role of gut microbiota influencing the vulnerability of brain to oxidative stress, and a budding causative in Alzheimer's and Parkinson's disease.
Journal ArticleDOI
Interplay of gut microbiota and oxidative stress: Perspective on neurodegeneration and neuroprotection
TL;DR: In this paper, the authors focused on the potential role of gut microbiota influencing the vulnerability of brain to oxidative stress, and a budding causative in Alzheimer's and Parkinson's disease.
Journal ArticleDOI
Interplay of Good Bacteria and Central Nervous System: Cognitive Aspects and Mechanistic Considerations.
TL;DR: A review of the studies considering beneficial effects of either gut microbiota or probiotic bacteria on the brain cognitive function in the healthy and disease statuses is presented in this article, where the authors have shown that the existence of a healthy gut microbiota is crucial for normal cognitive processing.
Journal ArticleDOI
Short-chain fatty acids-producing probiotics: A novel source of psychobiotics.
TL;DR: In this article, a review summarizes existing knowledge on the neuroprotective effects of SCFAs-producing bacteria in neurological disorders via modulating microbiota-gut-brain axis and illustrate their possible mechanisms by which SCFA-containing bacteria may act on these disorders.
References
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Journal ArticleDOI
Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour
John F. Cryan,Timothy G. Dinan +1 more
TL;DR: The emerging concept of a microbiota–gut–brain axis suggests that modulation of the gut microbiota may be a tractable strategy for developing novel therapeutics for complex CNS disorders.
Journal ArticleDOI
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Javier A. Bravo,Paul Forsythe,Marianne V. Chew,Emily Escaravage,Hélène M. Savignac,Timothy G. Dinan,John Bienenstock,John F. Cryan +7 more
TL;DR: Chronic treatment with L. rhamnosus induced region-dependent alterations in GABAB1b mRNA in the brain with increases in cortical regions and concomitant reductions in expression in the hippocampus, amygdala, and locus coeruleus, in comparison with control-fed mice, highlighting the important role of bacteria in the bidirectional communication of the gut–brain axis.
Journal ArticleDOI
The Hippocampal-VTA Loop: Controlling the Entry of Information into Long-Term Memory
John E. Lisman,Anthony A. Grace +1 more
TL;DR: The concept that the hippocampus and the midbrain dopaminergic neurons of the ventral tegmental area (VTA) form a functional loop is developed and support a model whereby the hippocampal-VTA loop regulates the entry of information into long-term memory.
Journal ArticleDOI
Alzheimer's Disease and Parkinson's Disease
TL;DR: The genetics of these familial forms of Alzheimer's and Parkinson's disease are examined to improve understanding of the pathobiology of the more common, sporadic forms of the diseases.
Journal ArticleDOI
Cognitive decline in Parkinson disease
Dag Aarsland,Byron Creese,Byron Creese,Marios Politis,K. Ray Chaudhuri,Dominic Ffytche,Daniel Weintraub,Daniel Weintraub,Daniel Weintraub,Clive Ballard,Clive Ballard +10 more
TL;DR: New genetic evidence indicates that in addition to the APOE*ε4 allele (an established risk factor for AD), GBA mutations and SCNA mutations and triplications are associated with cognitive decline in PD, whereas the findings are mixed for MAPT polymorphisms.