Book ChapterDOI
Neurosteroid Influences on Neuronal Excitability
Doodipala Samba Reddy
- pp 23-40
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The article was published on 2013-01-24. It has received 1 citations till now. The article focuses on the topics: Allopregnanolone & Neuroactive steroid.read more
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Journal ArticleDOI
Catamenial Epilepsy: Discovery of an Extrasynaptic Molecular Mechanism for Targeted Therapy
TL;DR: Molecular mechanisms such as these offer a strong rationale for the clinical development of a neurosteroid replacement therapy for catamenial epilepsy and extrasynaptic δGABA-A receptors are upregulated during perimenstrual-like neuroendocrine milieu, resulting in enhanced antiseizure efficacy of neurosteroids inCatamenial models.
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Journal ArticleDOI
Steroid Hormone Metabolites are Barbiturate-Like Modulators of the GABA Receptor
Maria Dorota Majewska,Neil L. Harrison,Rochelle D. Schwartz,Jeffery L. Barker,Steven M. Paul +4 more
TL;DR: Two metabolites of the steroid hormones progesterone and deoxycorticosterone are potent barbiturate-like ligands of the gamma-aminobutyric acid (GABA) receptor-chloride ion channel complex and potentiated the inhibitory actions of GABA in cultured rat hippocampal and spinal cord neurons, which may explain the ability of certain steroid hormones to rapidly alter neuronal excitability.
Journal ArticleDOI
Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders
Rainer Rupprecht,Vassilios Papadopoulos,Gerhard Rammes,Thomas C. Baghai,Jinjiang Fan,Nagaraju Akula,Ghislaine Groyer,David H. Adams,Michael Schumacher +8 more
TL;DR: The translocator protein (18 kDa) (TSPO) is localized primarily in the outer mitochondrial membrane of steroid-synthesizing cells, including those in the central and peripheral nervous system, which is a prerequisite for steroid synthesis.
Journal ArticleDOI
Endogenous neurosteroids regulate GABAA receptors through two discrete transmembrane sites.
TL;DR: Two discrete binding sites in the GABAA receptor’s transmembrane domains are identified that mediate the potentiating and direct activation effects of neurosteroids and provide a unique opportunity for the development of new therapeutic, neurosteroid-based ligands and transgenic disease models of Neurosteroid dysfunction.
Journal Article
Structure-activity relationships for steroid interaction with the gamma-aminobutyric acidA receptor complex.
TL;DR: Comparison of the structure-activity relationship data obtained in this study with those for steroid-induced general anesthesia strongly suggests that steroidal anesthesia may result from the interaction between steroids and the GABAA receptor.
Journal ArticleDOI
Ovarian cycle–linked changes in GABA A receptors mediating tonic inhibition alter seizure susceptibility and anxiety
TL;DR: Ovarian cycle-linked changes in GABA A receptors mediating tonic inhibition alter seizure susceptibility and anxiety as mentioned in this paper, leading to increased seizure susceptibility, anxiety, and seizure onset.