Journal ArticleDOI
Neutrophils as protagonists and targets in chronic inflammation
Oliver Soehnlein,Sabine Steffens,Andrés Hidalgo,Andrés Hidalgo,Christian Weber,Christian Weber +5 more
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TLDR
This Review aims to summarize the current understanding of the roles of neutrophils in chronic inflammation, with a focus on how they communicate with other immune and non-immune cells within tissues.Abstract:
Traditionally, neutrophils have been acknowledged to be the first immune cells that are recruited to an inflamed tissue and have mainly been considered in the context of acute inflammation. By contrast, their importance during chronic inflammation has been studied in less depth. This Review aims to summarize our current understanding of the roles of neutrophils in chronic inflammation, with a focus on how they communicate with other immune and non-immune cells within tissues. We also scrutinize the roles of neutrophils in wound healing and the resolution of inflammation, and finally, we outline emerging therapeutic strategies that target neutrophils.read more
Citations
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Triggering and resolution of inflammation in NASH.
TL;DR: The authors comprehensively discuss the key factors that trigger hepatic inflammation, as well as the pathways involved in inflammation resolution, which help to design targeted therapies able to halt or reverse disease progression in NASH.
Journal ArticleDOI
Heterogeneity of neutrophils
TL;DR: It is suggested that neutrophil heterogeneity is an important feature of immune pathophysiology, such that co-option of the mechanisms of diversification by cancer or other disorders contributes to disease progression.
Journal ArticleDOI
The big five in fibrosis: Macrophages, myofibroblasts, matrix, mechanics, and miscommunication.
Pardis Pakshir,Boris Hinz +1 more
TL;DR: Understanding the mechanical and chemical state of the matrix and its effects on cellular processes will be essential to address diseases that are characterized by dysfunctional matrix, such as fibrosis.
Journal ArticleDOI
A dysbiotic microbiome triggers T H 17 cells to mediate oral mucosal immunopathology in mice and humans.
Nicolas Dutzan,Nicolas Dutzan,Tetsuhiro Kajikawa,Loreto Abusleme,Loreto Abusleme,Teresa Greenwell-Wild,Carlos E. Zuazo,Tomoko Ikeuchi,Laurie Brenchley,T. Abe,C. Hurabielle,C. Hurabielle,Daniel Martin,Robert J. Morell,Alexandra F. Freeman,Vanja Lazarevic,Giorgio Trinchieri,Patricia I. Diaz,Steven M. Holland,Yasmine Belkaid,George Hajishengallis,Niki M. Moutsopoulos +21 more
TL;DR: An expansion of resident memory T helper 17 (TH17) cells in human periodontitis is demonstrated and this study highlights distinct functions of TH17 cells in oral immunity and inflammation and paves the way to a new targeted therapeutic approach for the treatment ofperiodontitis.
Journal ArticleDOI
Neutrophils as regulators of cardiovascular inflammation.
Carlos Silvestre-Roig,Quinte Braster,Almudena Ortega-Gomez,Oliver Soehnlein,Oliver Soehnlein +4 more
TL;DR: The influence of traditional and novel cardiovascular risk factors on neutrophil production and function is discussed and the current knowledge of the contribution of neutrophils to the different stages of atherosclerosis, including atherogenesis, plaque destabilization and plaque erosion is appraised.
References
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Identification of splenic reservoir monocytes and their deployment to inflammatory sites
Filip K. Swirski,Matthias Nahrendorf,Martin Etzrodt,Martin Etzrodt,Moritz Wildgruber,Virna Cortez-Retamozo,Peter Panizzi,Jose-Luiz Figueiredo,Rainer H. Kohler,Aleksey Chudnovskiy,Peter Waterman,Elena Aikawa,Thorsten R. Mempel,Peter Libby,Ralph Weissleder,Mikael J. Pittet +15 more
TL;DR: It is shown that bona fide undifferentiated monocytes reside in the spleen and outnumber their equivalents in circulation and identifies splenic monocytes as a resource that the body exploits to regulate inflammation.
Journal ArticleDOI
Immune attack: the role of inflammation in Alzheimer disease
TL;DR: As inflammation in AD primarily concerns the innate immune system — unlike in 'typical' neuroinflammatory diseases such as multiple sclerosis and encephalitides — the concept of neuroinflammation in AD may need refinement.
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Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock
Thomas Vogl,Klaus Tenbrock,Stephan Ludwig,Nadja Leukert,Christina Ehrhardt,Marieke A. D. van Zoelen,Wolfgang Nacken,Dirk Foell,Tom van der Poll,Clemens Sorg,Johannes Roth +10 more
TL;DR: It is demonstrated that mice lacking Mrp8-Mrp14 complexes are protected from endotoxin-induced lethal shock and Escherichia coli–induced abdominal sepsis, indicating new inflammatory components that amplify phagocyte activation during sepsi upstream of TNFα–dependent effects.
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Neutrophils in cancer: neutral no more
TL;DR: This Review discusses the involvement of neutrophils in cancer initiation and progression, and their potential as clinical biomarkers and therapeutic targets.
Journal ArticleDOI
Neutrophils Activate Plasmacytoid Dendritic Cells by Releasing Self-DNA–Peptide Complexes in Systemic Lupus Erythematosus
Roberto Lande,Dipyaman Ganguly,Dipyaman Ganguly,Valeria Facchinetti,Loredana Frasca,Curdin Conrad,Josh Gregorio,Josh Gregorio,Stephan Meller,Georgios Chamilos,Rosalie Sebasigari,Valeria Riccieri,Roland L. Bassett,Hideki Amuro,Shirou Fukuhara,Tomoki Ito,Yong-Jun Liu,Michel Gilliet +17 more
TL;DR: An important role is shown for neutrophils in lupus pathogenesis, whereby neutrophil activated by anti-self antibodies release NETs, which contain antimicrobial peptides complexed with self-DNA and can entrap bacteria, enabling them to be killed.