New Classification of Neisseria meningitidis by Means of Bactericidal Reactions
Citations
499Â citations
Cites background or methods or result from "New Classification of Neisseria men..."
...The previous serotyping schemes of Gold and Wyle [1], Kasper et al....
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...[3] and Gold and Wyle [1], respectively....
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...These initial observations were extended by Gold and Wyle [1], who in 1970 reported that group C meningococci could be subdivided into...
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...A number of serotyping schemes have been used to identify antigenically related strains of Neisseria meningitidis serogroups B and C [1-4] and have been the subject of earlier reviews [5, 6]....
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410Â citations
Cites background or methods from "New Classification of Neisseria men..."
...N. meningitidis serogroup A and C polysaccharide-specific antibodies were measured by a standardized ELISA (3, 8)....
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...In addition, there was a significant (P , 0.001) correlation between SBA titers and ELISA antibody concentrations for both serogroup A and C....
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...These meningococcal QC sera (CDC QC sera) and the ELISA reference serum are maintained as a lyophilized collection at CDC and were rehydrated with sterile endotoxin-free water just before use in the assay....
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...This standardized serogroup A and C meningococcal SBA, modified from the method recommended by WHO, gave serogroupspecific, reproducible bactericidal titers that correlated with ELISA antibody concentrations....
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...In addition, the serum titers were higher with GBSS-gelatin....
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331Â citations
315Â citations
Cites background from "New Classification of Neisseria men..."
...The noncapsular serotypespecific antigens, which are present in the outer membrane protein of meningococci [28], can be differentiated by bactericidal [29] and a variety of other methods [28]....
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315Â citations
References
1,028Â citations
"New Classification of Neisseria men..." refers background in this paper
...(7), also using a bactericidal assay, subsequently reported that there is complex antigenic diversity within group C strains....
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...The essential difficulty in recognizing strain differences within a serogroup lies in the fact that there are two distinct kinds of bactericidal antibodies present in rabbit anti-meningococcal serum (7)....
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...(7) that distinct antigenic differences exist between strains within a serogroup have been confirmed....
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...(7), seven group C strains were initially chosen for study: 60E, 1381, 1714, 913, 126E, 1185, and 321....
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391Â citations
"New Classification of Neisseria men..." refers background or methods in this paper
...With fixed sheep red blood cells sensitized with C polysaccharide (9), transitory low titers (1:32 or less) of hemagglutinating antibody were detected within 1 week after immunization....
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...(9) and referred to hereafter as C polysaccharide] was prepared in New Zealand rabbits by the method of Plescia et al....
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