New Gatekeepers of Reproduction: GPR54 and Its Cognate Ligand, KiSS-1
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Cites background from "New Gatekeepers of Reproduction: GP..."
...Thus, our data suggest that although Kiss1r is present in the testis of adult monkey but more probably involved in other kisspeptin actions which may not be directly related to testosterone and inhibin secretion....
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...Kisspeptin act through G protein-coupled receptor (Kiss1r) (Lee et al., 1999; Kotani et al., 2001; Muir et al., 2001; Ohtaki et al., 2001)....
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...These results of lack of effect of kisspeptin on testosterone release are in accordance with our expression analysis where we did not find any expression of Kiss1r in the Leydig cells....
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...Continuous peripheral administration of kisspeptins to monkeys and rodents desensitised the Kiss1r (Seminara & Kaiser, 2005; Thompson et al., 2006; Ramaswamy et al., 2008)....
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...Kiss1/Kiss1r system is not only involved in signalling cascades at central level but has also been evidenced to play role in peripheral organs (neocortex of foetal adrenals, pancreatic islet endocrine cells as well (Nakamura et al., 2007; Hauge-Evans et al., 2006)....
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