New Gatekeepers of Reproduction: GPR54 and Its Cognate Ligand, KiSS-1
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...These findings suggest that kisspeptin–GPR54 signaling is critical for sexual maturation in humans and mice, but precisely how and where this signaling occurs and its relationship to puberty remain a mystery (Seminara and Kaiser, 2005)....
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...Thus, it seems plausible that kisspeptin–GPR54 signaling within the GnRH neuronal network is critical for the pubertal activation of GnRH neurons (Popa et al., 2005; Seminara and Kaiser, 2005), and the results of recent studies support this concept....
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...Hence, as a whole, these investigations have laid the foundation for the concept that kisspeptin-GPR54 signaling within the GnRH neuronal network may be a “gatekeeper” for puberty onset (Seminara and Kaiser, 2005)....
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224 citations
Cites background from "New Gatekeepers of Reproduction: GP..."
...Identification and characterization of the physiological roles of the so-called KiSS-1 system is a major breakthrough in modern Neuroendocrinology that has revolutionized the area of vertebrate reproduction (de Roux et al., 2003; Seminara et al., 2003; Matsui et al., 2004; Kaiser and Kuohung, 2005; Seminara, 2005; Seminara and Kaiser, 2005; Gottsch et al., 2006; Roa and Tena-Sempere, 2007; Roa et al., 2008)....
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...…in modern Neuroendocrinology that has revolutionized the area of vertebrate reproduction (de Roux et al., 2003; Seminara et al., 2003; Matsui et al., 2004; Kaiser and Kuohung, 2005; Seminara, 2005; Seminara and Kaiser, 2005; Gottsch et al., 2006; Roa and Tena-Sempere, 2007; Roa et al., 2008)....
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173 citations
172 citations
Cites background from "New Gatekeepers of Reproduction: GP..."
...…including kisspeptin 54 (K54), K14, K13, and K10, of which the latter exerts ell Metabolism 19, 667–681, April 1, 2014 ª2014 Elsevier Inc. 667 (legend continued on next page) 668 Cell Metabolism 19, 667–681, April 1, 2014 ª2014 Elsevier Inc. full biological effects (Seminara and Kaiser, 2005)....
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170 citations
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