New Insights in Therapy for Food Allergy.
Cristobalina Mayorga,Francisca Palomares,José A Cañas,Natalia Pérez-Sánchez,Rafael Núñez,María José Torres,Francisca Gómez +6 more
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TLDR
In this article, a review illustrates the IgE-mediated food hypersensitivity and provides a current description of the diagnostic strategies and advances in different treatments for food allergy, including specific immunotherapy, including different routes of administration and new therapeutic approaches, such as hypoallergens and nanoparticles.Abstract:
Food allergy is an increasing problem worldwide, with strict avoidance being classically the only available reliable treatment. The main objective of this review is to cover the latest information about the tools available for the diagnosis and treatment of food allergies. In recent years, many efforts have been made to better understand the humoral and cellular mechanisms involved in food allergy and to improve the strategies for diagnosis and treatment. This review illustrates IgE-mediated food hypersensitivity and provides a current description of the diagnostic strategies and advances in different treatments. Specific immunotherapy, including different routes of administration and new therapeutic approaches, such as hypoallergens and nanoparticles, are discussed in detail. Other treatments, such as biologics and microbiota, are also described. Therefore, we conclude that although important efforts have been made in improving therapies for food allergies, including innovative approaches mainly focusing on efficacy and safety, there is an urgent need to develop a set of basic and clinical results to help in the diagnosis and treatment of food allergies.read more
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Surface-enhanced Raman spectroscopy relying on bimetallic Au-Ag nanourchins for the detection of the food allergen β-lactoglobulin.
TL;DR: In this article , a SERS-based method was designed to detect β-lactoglobulin (β-Lg), a major allergen of milk, utilizing aptamers to specifically anchor β-Lgl.
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Bifidobacterium longum subsp. longum 51A Attenuates Signs of Inflammation in a Murine Model of Food Allergy
Spencer S. Santos,V.C. Miranda,Luísa Martins Trindade,Valbert Nascimento Cardoso,Diego Carlos dos Reis,Geovanni Dantas Cassali,Jacques Robert Nicoli,Denise Carmona Cara,Flaviano S. Martins +8 more
TL;DR: In this article, the authors evaluated the probiotic effect of Bifidobacterium longum subsp. longum 51A (BL51A) in a murine model of ovalbumin (OVA) food allergy, as well as investigate the effect of the dose and viability of the bacteria on the proposed model.
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Intestinal Uptake and Tolerance to Food Antigens
TL;DR: The pathways through which food antigens enter the intestine are summarized and the proposed mechanisms describing how the intestine acquires and tolerates foodAntigens are reviewed to provide additional clues for potential treatment options for food allergy.
Journal ArticleDOI
Basophil Activation Test Utility as a Diagnostic Tool in LTP Allergy
José A Cañas,Natalia Pérez-Sánchez,Leticia Lopera-Doblas,Francisco Palomares,Ana Molina,Joan Bartra,María José Torres,Francisca Gómez,Cristobalina Mayorga +8 more
TL;DR: BAT showed differences in LTP-allergic patients tolerant to peanut using its corresponding LTP, Ara h 9, and an optimal cut-off was established from ROC curves, showing a significant positive percentage of BAT in patients compared to controls and great values of sensitivity and specificity.
Journal ArticleDOI
IgE-Mediated food allergy: Current diagnostic modalities and novel biomarkers with robust potential.
Qiang Xie,Wen-Tong Xue +1 more
TL;DR: How traditional diagnostic modalities guide appropriate diagnosis and management of FA in clinical practice are discussed, as well as the potential of the latest biomarkers for the diagnosis, monitoring, and prediction of FA are uncovered.
References
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