New insights into the function and regulation of mitochondrial fission.
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TLDR
Current knowledge regarding the regulation and physiologic relevance of Drp1-dependent mitochondrial fission is reviewed: the initial recruitment and assembly ofDrp1 on the mitochondria fission foci, regulation of Dr p1 activity by post-translational modifications, and the role of mitochondrial fissions in cell pathophysiology are reviewed.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2013-05-01 and is currently open access. It has received 396 citations till now. The article focuses on the topics: Mitochondrial fission & MFN2.read more
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Mitochondrial dynamics: overview of molecular mechanisms
TL;DR: An overview of the molecular mechanisms that govern mitochondrial fission and fusion in mammals is described and several members of the machinery can undergo post-translational modifications modulating these processes.
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Mitochondrial energetics in the kidney
TL;DR: Implementing compounds that stimulate mitochondrial biogenesis can restore mitochondrial and renal function in mouse models of AKI and diabetes mellitus and inhibiting the fission protein dynamin 1-like protein (DRP1) might ameliorate ischaemic renal injury by blocking mitochondrial fission.
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The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission
Ruchika Anand,Timothy Wai,Michael J. Baker,Nikolay Kladt,Astrid Schauss,Elena I. Rugarli,Thomas Langer,Thomas Langer +7 more
TL;DR: OPA1 processing by YEM1L and OMA1 is dispensable for mitochondrial fusion and instead drives mitochondrial fragmentation, which is crucial for mitochondrial integrity and quality control.
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hFis1, a novel component of the mammalian mitochondrial fission machinery. Vol. 278 (2003) 36373–36379
TL;DR: In this article, the authors identified a mammalian protein called hFis1, which is the orthologue of the yeast Fis1p known to participate in yeast mitochondrial division, and when overexpressed in various cell types, localized to the outer mitochondrial membrane and induced mitochondrial fission.
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Metabolic control of cell death
TL;DR: The existence of several “metabolic checkpoints” is proposed, refined molecular mechanisms that sense a panel of metabolic variables and emit one or more signals controlling cell fate, which might allow for the development of novel pharmacological approaches that block or stimulate cell death by inducing specific metabolic alterations.
References
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Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
TL;DR: It is shown that Parkin is selectively recruited to dysfunctional mitochondria with low membrane potential in mammalian cells and this recruitment promotes autophagy of damaged mitochondria and implicate a failure to eliminate dysfunctional mitochondira in the pathogenesis of Parkinson's disease.
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A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine
TL;DR: The mitochondria provide a direct link between the authors' environment and their genes and the mtDNA variants that permitted their forbears to energetically adapt to their ancestral homes are influencing their health today.
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Fission and selective fusion govern mitochondrial segregation and elimination by autophagy
Gilad Twig,Alvaro A. Elorza,Anthony J.A. Molina,Anthony J.A. Molina,Hibo Mohamed,Jakob D. Wikstrom,Gil Walzer,Linsey Stiles,Sarah E. Haigh,Steve Katz,Guy Las,Joseph Alroy,Min Wu,Bénédicte F. Py,Junying Yuan,Jude T. Deeney,Barbara E. Corkey,Orian S. Shirihai +17 more
TL;DR: Pulse chase and arrest of autophagy at the pre‐proteolysis stage reveal that fission followed by selective fusion segregates dysfunctional mitochondria and permits their removal by autophagic.
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Mechanisms of mitophagy
TL;DR: Mitophagy, the specific autophagic elimination of mitochondria, has been identified in yeast, and in mammals during red blood cell differentiation, mediated by NIP3-like protein X (NIX; also known as BNIP3L).
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Mitochondrial Fission, Fusion, and Stress
TL;DR: In their Perspective, Hoppins and Nunnari explain that the endoplasmic reticulum is an active participant in mitochondrial division and discuss how mitochondrial dynamics and cell death are linked.