Figure 7. NFIC restrains formation of preneoplastic lesions in the pancreas. (A) 826 IHC analysis of NFIC expression shows down-regulation in PanINs (right) and tumor 827 cells compared to adjacent normal acinar cells (left). (B) NFIC mRNA analysis of tumor 828 samples and normal adjacent tissue assessed by microarrays (Janky et al., 2016) 829 showing reduced expression in tumor samples. (C,D) IHC analysis of NFIC expression 830 in human PDAC specimens showing reduced expression in tumoral cells (arrow) 831 compared to normal adjacent tissue or stromal cells (arrowheads). (E,F) Histological 832 analysis of the pancreas of KRasG12V or KRasG12V;Nfic-/- 14-20 week old mice showing 833 increased number of PanINs and area occupied by pre-neoplastic lesions 834 (n>5/genotype). 835
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