Journal ArticleDOI
Nitrido complexes of technetium with tertiary phosphines and arsines
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TLDR
In this paper, the Diamagnetic Technetium(V) complexes of general formulae [TcNX 2 (Ph 3 Y) 2 ] and [T cNX 3 (Me 2 PhP) 3 ] (X = Cl, Br; Y = P, As) were prepared starting from TcCl 4 − and TcNBr 4 −, respectively and characterized.About:
This article is published in Polyhedron.The article was published on 1988-01-01. It has received 48 citations till now.read more
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Journal ArticleDOI
Chemistry of the strong electrophilic metal fragment [(99)Tc(N)(PXP)](2+) (PXP = diphosphine ligand). A novel tool for the selective labeling of small molecules.
Cristina Bolzati,Alessandra Boschi,Licia Uccelli,Francesco Tisato,Fiorenzo Refosco,Aldo Cagnolini,Adriano Duatti,Sushumna Prakash,G. Bandoli,Andrea Vittadini +9 more
TL;DR: It was found that fac-[M(N)Cl(2)(PXP)] complexes easily underwent ligand-exchange reactions with bidentate donor ligands such as mercaptoacetic acid (NaHL(1)), S-methyl 2-methyldithiocarbazate (H(2)L(2)), diethyldithuocarbamate sodium salt (NaL(3)), and N-acetyl-L-cysteine (H
Journal Article
Synthesis and Biologic Evaluation of Monocationic Asymmetric 99mTc-Nitride Heterocomplexes Showing High Heart Uptake and Improved Imaging Properties
Alessandra Boschi,Licia Uccelli,Cristina Bolzati,Adriano Duatti,N. Sabba,E. Moretti,Giovanni Di Domenico,Guido Zavattini,Fiorenzo Refosco,Melchiore Giganti +9 more
TL;DR: Investigation of the preparation, characterization, and first biologic evaluation in rats of a novel class of monocationic (99m)Tc heart imaging agents demonstrated that these radiopharmaceuticals localize selectively in the myocardium of rats and are retained in this region for a prolonged time.
Synthon for Use with Biologically Active Molecules. The N-(2-Methoxyphenyl)piperazyl-cysteine Analogues as Examples
Cristina Bolzati,Ashfaq Mahmood,Erica Malagò,Licia Uccelli,Alessandra Boschi,Alun G. Jones,Fiorenzo Refosco,Adriano Duatti,Francesco Tisato,Corso Stati Uniti +9 more
TL;DR: Assessment of the in vitro 5HT(1A) receptor-affinity of the technetium complexes revealed that only the anti-PNP4 complex possesses some affinity for the receptor, but displayed negligible brain uptake in biodistribution studies in rats in vivo.
Journal ArticleDOI
Synthesis, Solution-State and Solid-State Structural Characterization of Monocationic Nitrido Heterocomplexes (M(N)(DTC)(PNP)) (M 99 Tc, Re; DTC Dithiocarbamate; PNP Heterodiphosphane)
Cristina Bolzati,Fiorenzo Refosco,Aldo Cagnolini,Francesco Tisato,Alessandra Boschi,Adriano Duatti,Licia Uccelli,Alessandro Dolmella,Ester Marotta,Michela Tubaro +9 more
TL;DR: In this article, it was shown that a mixed coordination sphere, composed by a combination of π-donor and πacceptor atoms around the [M≡N]2+ group, constitutes a highly stable system.
Book ChapterDOI
The Coordination Chemistry of Technetium
TL;DR: In this paper, the coordination chemistry of technetium was described focusing on the coordination properties of five-coordinate and pseudo-octahedral TcCl 6 units with aminocarboxylato ligands.
References
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Journal ArticleDOI
Studies of technetium complexes. 9. Use of the tetrachloronitridotechnetate(VI) anion for the preparation of nitrido complexes of technetium. Crystal structure of bis(8-quinolinethiolato)nitridotechnetium(V)
TL;DR: In this article, a single-crystal X-ray structure determination of bis(8-quinolinethiolato)nitridotechnetium (V), (TcN(C/sub 9/H/sub 6/NS)/sub 2/), is reported.
Journal ArticleDOI
Substitution reactions of 99mTcNCl4−. A route to a new class of 99mTc-radiopharmaceuticals
John Baldas,John Bonnyman +1 more
TL;DR: Biological distribution studies in mice of these complexes showed that the presence of the nitrido group produced a radiopharmaceutical with different biological behaviour to that produced when conventional reduction methods are used with the same ligand.
Journal ArticleDOI
Lipophilic technetium complexes
TL;DR: In this article, a series of technetium complexes with different alkyl dithiocarbamates, Dithiophosphates and xanthates has been prepared at tracer level (10−4 molar) starting from hydrazine-reduced pertechnetate and Tc(V) gluconate, respectively.