Nitrogen dioxide and carbonate radical anion: two emerging radicals in biology.
Citations
5,514 citations
Cites background from "Nitrogen dioxide and carbonate radi..."
...6 10 4 M 1 · s 1 at 37°C) gives rise to an unstable product (nitrosoperoxycarbonate, ONOOCO2 ), which rapidly homolyzes into the CO3 (carbonate radical) and NO2 (34)....
[...]
...A second mechanism of tyrosine nitration relies on the generation of the NO2• radical by various heme-peroxidases (mainly myeloperoxidase and eosinophil peroxidase) in the presence of hydrogen peroxide (438,1314,1390)....
[...]
...II) Tyrosine nitration: Protein tyrosine nitration is a covalent protein modification resulting from the addition of a nitro (-NO2) group adjacent to the hydroxyl group on the aromatic ring of tyrosine residues (464)....
[...]
...The direct reaction of peroxynitrite with CO2 (4.6 × 104 M−1 · s−1 at 37°C) gives rise to an unstable product (nitrosoperoxycarbonate, ONOOCO2 −), which rapidly homolyzes into the CO3 − • (carbonate radical) and NO2 • (34)....
[...]
...Peroxynitrite can yield hydroxyl radical and nitrogen dioxide (NO2•) during the homolytic decomposition of peroxynitrous acid (1054)....
[...]
2,430 citations
Cites background from "Nitrogen dioxide and carbonate radi..."
...NO 2 þ CO 3 : Both NO 2 (nitrogen dioxide) and CO 3 (carbonate radical) are powerfully oxidizing radicals – not as bad as OH• but still not pleasant (Augusto et al. 2002)....
[...]
...NO 2 is also produced in vivo by myeloperoxidase and from ONOO (Augusto et al. 2002)....
[...]
...NO 2 þ OH Peroxynitrite also reacts with CO2 (Greenacre and Ischiropoulos 2001; Alvarez and Radi 2003; Ischiropoulos and Beckman 2003) ONOO þ CO2 !...
[...]
...ONOOCOO ONOOCOO !...
[...]
...For example, OH oxidizes carbonate ion to carbonate radical (Augusto et al. 2002)....
[...]
1,376 citations
946 citations
804 citations
References
21,528 citations
15,827 citations
11,238 citations
9,887 citations