NKCC1 Chloride Importer Antagonists Attenuate Many Neurological and Psychiatric Disorders
Citations
156 citations
136 citations
Cites background from "NKCC1 Chloride Importer Antagonists..."
...Selective NKCC1 inhibitors known as diuretics including bumetanide and furosemide improve neurological behavior control and lower anxiety, neuropathic pain, and schizophrenia in animals and patients (Ben-Ari, 2017)....
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93 citations
Cites background from "NKCC1 Chloride Importer Antagonists..."
...These outcomes have been debated and it was argued that bumetanide had not been used as a primary agent to treat the neonatal seizures and that the effect of bumetanide as monotherapy for seizure reduction had not been tested (Ben-Ari, 2017; Pressler et al., 2015)....
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...This notion has evoked studies into the application of bumetanide to this group of patients (Ben-Ari, 2017)....
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...However, in certain pathophysiological conditions fine-tuning of [Cl-]i can become dysregulated and affect GABAergic inhibition (Ben-Ari, 2017)....
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85 citations
Cites background from "NKCC1 Chloride Importer Antagonists..."
...Because of the lack of pharmaceutical reagents that enhance KCC2 expression, bumetanide, a blocker of the inward chloride transporter NKCC1 that counteracts KCC2, has been used as an alternative (74)....
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72 citations
Cites background from "NKCC1 Chloride Importer Antagonists..."
...2 Bumetanide The diuretic bumetanide, a chlorideimporter antagonist, targets abnormalities in intracellular GABAA chloride levels [56]....
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...It is believed that some children with ASD have a failure in this developmental change in KCC2 expression resulting in GABAA remaining excitatory [56]....
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References
2,045 citations
"NKCC1 Chloride Importer Antagonists..." refers background in this paper
...The developmental reduction of (Cl )I levels is mediated primarily by two chloride cotransporters – the NKCC1 importer (Box 1) and the KCC2 chloride exporter [1,4,5]....
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1,480 citations
"NKCC1 Chloride Importer Antagonists..." refers background in this paper
...Deficits in KCC2 have been observed in human transformed progenitor cells from RTT patients [84], suggesting that the delayed expression of KCC2 during development might explain the late manifestations of RTT....
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...Mecp2 also regulates the timing of critical period of visual plasticity with an important role of paravalbumin interneurons, stressing the importance of GABA signaling and developmental processes in RTT [82]....
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...Knocking out Mecp2 selectively from GABAergic interneurons recapitulates some of RTT features [74,76,77]....
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...Rett Syndrome (RTT)...
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...Different symptoms of RTT may manifest through specific loss of Mecp2 in different brain regions that are also associated with an excitatory/inhibitory imbalance [73,74]....
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1,283 citations
1,252 citations
"NKCC1 Chloride Importer Antagonists..." refers background in this paper
...Administration of the antiepileptic agent valproic acid (VPA) during gestation augments the incidence of ASD in humans [49]....
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...Discovered two decades ago, the intrauterine valproate model is one the most investigated animal model of ASD, as VPA mimics autistic features and developmental disorders in many animal species [49]....
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1,233 citations
"NKCC1 Chloride Importer Antagonists..." refers background in this paper
...Different symptoms of RTT may manifest through specific loss of Mecp2 in different brain regions that are also associated with an excitatory/inhibitory imbalance [73,74]....
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