NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes.
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...…brain, expression of inflammasome components has also been reported in other cell types of the CNS, including neurons (Kaushal et al, 2015), astrocytes (Freeman et al, 2017), perivascular CNS macrophages (Kawana et al, 2013), oligodendrocytes (Mckenzie et al, 2018), and endothelial cells (Gong et…...
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"NLR members NLRC4 and NLRP3 mediate..." refers methods in this paper
...…for nLrc4 in MS lesions Ab MS brain Control brain Plaque Adjacent white matter Adjacent gray matter NAWM NAGM NLRC4 39.585 28.714 1.511 0 0 Immunofluorescence indicating NLRC4 presence in tissue sections was quantified by National Institutes of Health ImageJ software (Schneider et al., 2012)....
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...Immunofluorescence in tissue sections was quantified by the National Institutes of Health ImageJ software (Schneider et al., 2012)....
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...National Institutes of Health ImageJ software (Schneider et al., 2012)....
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"NLR members NLRC4 and NLRP3 mediate..." refers background in this paper
...Some notable examples include NLRP1 (Boyden and Dietrich, 2006), NLRP3 (Kanneganti et al., 2006; Mariathasan et al., 2006; Martinon et al., 2006; Sutterwala et al., 2006), NLRP6 (Anand et al., 2012), NLRP7 (Khare et al., 2012), NLRP12 (Vladimer et al., 2012), NLRC4 (Zhao et al., 2011), NLRC5 (Davis…...
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...Some notable examples include NLRP1 (Boyden and Dietrich, 2006), NLRP3 (Kanneganti et al., 2006; Mariathasan et al., 2006; Martinon et al., 2006; Sutterwala et al., 2006), NLRP6 (Anand et al....
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"NLR members NLRC4 and NLRP3 mediate..." refers background in this paper
...Microglial cells are resident immune cells of the CNS that release cytokines and chemokines and also phagocytose dead cells, cellular debris, and invading pathogens (Hanisch and Kettenmann, 2007; Napoli and Neumann, 2009)....
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