Journal ArticleDOI
NMDA receptor affinities of 1,2-diphenylethylamine and 1-(1,2-diphenylethyl)piperidine enantiomers and of related compounds.
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The synthesis of the dicyclohexyl analogues of DPEA and related compounds were tested as inhibitors of [(3)H]MK-801 binding to rat brain membranes and exhibited stereospecific sensitivity to the modulator spermine.About:
This article is published in Bioorganic & Medicinal Chemistry.The article was published on 2009-05-01. It has received 34 citations till now. The article focuses on the topics: Channel blocker.read more
Citations
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Book ChapterDOI
1,2-Diarylethylamine- and Ketamine-Based New Psychoactive Substances.
Jason Wallach,Simon D. Brandt +1 more
TL;DR: Two structurally distinct classes that have appeared as dissociative-based new psychoactive substances (NPS) are the 1,2-diarylethylamines and β-keto-arylcyclohexylamines.
Journal ArticleDOI
A large amount of new designer drug diphenidine coexisting with a synthetic cannabinoid 5-fluoro-AB-PINACA found in a dubious herbal product
TL;DR: In this paper, the authors identified the coexistence of a new type of dubious drug (diphenidine) with the synthetic cannabinoid 5-fluoro-AB-PINACA.
Journal ArticleDOI
Test purchase, synthesis, and characterization of 2-methoxydiphenidine (MXP) and differentiation from its meta- and para-substituted isomers
Gavin McLaughlin,Noreen Morris,Pierce V. Kavanagh,John D. Power,John E. O'Brien,Brian Talbot,Simon P. Elliott,Jason Wallach,Khoa Hoang,Hamilton Morris,Simon D. Brandt +10 more
TL;DR: Analytical data obtained for the three purchased samples were consistent with the synthesized 2-MXP standard and the differentiation between the isomers was possible, and distinct stability differences were observed for all three isomers during in-source collision-induced dissociation of the protonated molecule.
Journal ArticleDOI
Preparation and characterization of the ‘research chemical’ diphenidine, its pyrrolidine analogue, and their 2,2‐diphenylethyl isomers
Jason Wallach,Pierce V. Kavanagh,Gavin McLaughlin,Noreen Morris,John D. Power,Simon P. Elliott,Marion S. Mercier,David Lodge,Hamilton Morris,Nicola M. Dempster,Simon D. Brandt +10 more
TL;DR: 1,2- diphenylethylamines appears to reflect the exploration of alternatives to arylcyclohexylamine-type substances, such as methoxetamine, PCP and PCPy-based analogues that also show NMDA receptor activity as demonstrated here for diphenidine.
Journal ArticleDOI
Lefetamine-derived designer drugs N-ethyl-1,2-diphenylethylamine (NEDPA) and N-iso-propyl-1,2-diphenylethylamine (NPDPA): Metabolism and detectability in rat urine using GC-MS, LC-MSn and LC-HR-MS/MS
Carina S. D. Wink,Golo M. J. Meyer,Dirk K. Wissenbach,Andrea Jacobsen-Bauer,Markus R. Meyer,Hans H. Maurer +5 more
TL;DR: The aim of the present work was to study the phase I and phase II metabolism of these drugs in rats and to check for their detectability in urine using the authors' standard urine screening approaches (SUSA).
References
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疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A
TL;DR: PfPMP1）与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作�ly.
Journal ArticleDOI
Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction.
TL;DR: The analysis described shows K I does not equal I 50 when competitive inhibition kinetics apply; however, K I is equal to I 50 under conditions of either noncompetitive or uncompetitive kinetics.
Journal ArticleDOI
The Use of Diethyl Azodicarboxylate and Triphenylphosphine in Synthesis and Transformation of Natural Products
TL;DR: In this article, a reagent formed by combining diethyl azodicarboxylate (DEAD) and triphenylphosphine (TPP) could be utilized in the intermolecular dehydration between an alcohol and various acidic components such as carboxylic acids, phosphoric diesters, imides, and active methylene compounds.
Journal ArticleDOI
The assignment of absolute configuration by NMR
TL;DR: In this paper, the application of (S)-1,10-binaphthyl-2,20-diol as NMR chiral solvating agent (CSA) for omeprazole, and three of its analogs (lanso-, panto-, and rabe-prazole) was investigated.
Related Papers (5)
From PCP to MXE: a comprehensive review of the non-medical use of dissociative drugs.
Hamilton Morris,Jason Wallach +1 more