NMDA receptor-dependent switching between different gamma rhythm-generating microcircuits in entorhinal cortex
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...The slower frequency may be determined by a mixture of cellular and synaptic properties, including voltage- and calcium-gated potassium currents in pyramidal cells and the strength of recurrent excitatory connections (817, 1052, 1054), perhaps also involving specific subtypes of interneurons (667, 682, 758)....
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...…in different cortical layers (Oke et al., 2010; Ainsworth et al., 2012), different effects of neuromodulators on rhythms in different brain areas (Middleton et al., 2008; Roopun et al., 2008a), switches in temporal structure with changes in activation (Roopun et al., 2008b), fast rhythms nested…...
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Cites background from "NMDA receptor-dependent switching b..."
...(G) Schematic indicates the slice cut to separate layers II and III (left)....
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...…of nested gamma activity reported in the MEC of behaving animals (Chrobak and Buzsáki, 1998; Colgin et al., 2009) and much higher than the frequency of pharmacologically induced gamma oscillations (Cunningham et al., 2003; Dickson et al., 2000; Middleton et al., 2008; van Der Linden et al., 1999)....
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...Examples of synaptic currents (row 2), corresponding scalograms (row 3), and the mean scalograms for all experiments (row 4), each plotted as a function of the phase of theta stimulation, demonstrate that nested gamma is maintained when connections between layers II and III are cut (control) and after subsequent block of NMDA receptors with 50 mM D-APV but is abolished by complete block of iGluRs....
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...…pharmacological models of gamma activity in the MEC in which the frequency of excitatory drive to interneurons is less than the network gamma frequency (Cunningham et al., 2003) and in which NMDA receptor activation is required for oscillations generatedwithin layer II (Middleton et al., 2008)....
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...Blocking NMDA receptors abolishes pharmacologically induced gamma activity generated locally in layer II of the MEC and reveals lower-frequency activity that originates from layer III (Middleton et al., 2008)....
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References
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"NMDA receptor-dependent switching b..." refers background in this paper
...This mechanism can underlie gamma rhythms in a broad range of frequencies from around 20 Hz up to 70 Hz in the hippocampus (8) but cannot support higher frequencies such as those labeled as ‘‘high gamma’’ previously (9)....
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1,625 citations
"NMDA receptor-dependent switching b..." refers background in this paper
...The basic mechanism of generation of population gamma rhythms by local neuronal circuits reveals an absolute dependence on the influence of fast spiking inhibitory interneurons at the level of principal cell somata (5, 6),with the frequency dependent on the magnitude and kinetics of gamma aminobutyric acid (GABAA) receptor-mediated synaptic events (7)....
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1,529 citations
"NMDA receptor-dependent switching b..." refers background in this paper
...For example, removal of entorhinal cortex in vivo produces a slower gamma rhythm (39), whose origins appear to be in area CA3 (40)....
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985 citations
"NMDA receptor-dependent switching b..." refers background in this paper
...For example, removal of entorhinal cortex in vivo produces a slower gamma rhythm (39), whose origins appear to be in area CA3 (40)....
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899 citations