NMDA receptor-dependent switching between different gamma rhythm-generating microcircuits in entorhinal cortex
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263 citations
Cites background from "NMDA receptor-dependent switching b..."
...There have been some reports that NMDA-receptors on PV interneurons are more sensitive to pharmacologic blockade than receptors expressed on excitatory pyramidal cells, particularly in the hippocampus and entorhinal cortex (Grunze et al., 1996; Jones and Buhl, 1993; Middleton et al., 2008)....
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249 citations
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...…depolarization of interneurons in entorhinal cortex may serve to dynamically route inputs to the hippocampus, with CA3 networks being tuned to the goblet cell-mediated slower gamma rhythm and CA1 networks being tuned to the basket cell (higher frequency) gamma rhythm (Middleton et al., 2008a, b)....
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...Here, cholinergic activation via nicotinic receptors generates a gamma frequency local field potential oscillation that is independent of any kainate, AMPA or NMDA receptor activity [Fig 2(A); (Middleton et al., 2008a, b)]....
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...Further evidence from medial entorhinal cortex has shown that two anatomically distinct subclasses of local circuit interneuron in superficial layers compete for control over gamma rhythm generation (Middleton et al., 2008a, b; Fig....
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222 citations
197 citations
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...An example of the importance of such frequency matching is given by a striking observation (Middleton et al., 2008) that the rodent entorhinal cortex, in vitro, can produce two different frequencies of gamma rhythm, separated by ~10 Hz, depending on the activity of N-methyl-D-aspartate (NMDA)…...
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194 citations
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...The spatial and temporal segregation of EC gamma rhythms may engage different regions of the hippocampus in a task-specific manner (Charpak et al., 1995; Chrobak and Buzsáki, 1998; Middleton et al., 2008; Colgin et al., 2009)....
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...Gamma oscillations in the EC may arise from multiple mechanisms (Cunningham et al., 2003, 2004, 2006; Middleton et al., 2008)....
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...In agreement with in vitro studies (Cunningham et al., 2003; Middleton et al., 2008), we found that gamma oscillations independently emerged in different layers....
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References
2,404 citations
"NMDA receptor-dependent switching b..." refers background in this paper
...This mechanism can underlie gamma rhythms in a broad range of frequencies from around 20 Hz up to 70 Hz in the hippocampus (8) but cannot support higher frequencies such as those labeled as ‘‘high gamma’’ previously (9)....
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1,625 citations
"NMDA receptor-dependent switching b..." refers background in this paper
...The basic mechanism of generation of population gamma rhythms by local neuronal circuits reveals an absolute dependence on the influence of fast spiking inhibitory interneurons at the level of principal cell somata (5, 6),with the frequency dependent on the magnitude and kinetics of gamma aminobutyric acid (GABAA) receptor-mediated synaptic events (7)....
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1,529 citations
"NMDA receptor-dependent switching b..." refers background in this paper
...For example, removal of entorhinal cortex in vivo produces a slower gamma rhythm (39), whose origins appear to be in area CA3 (40)....
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985 citations
"NMDA receptor-dependent switching b..." refers background in this paper
...For example, removal of entorhinal cortex in vivo produces a slower gamma rhythm (39), whose origins appear to be in area CA3 (40)....
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899 citations