NMP-7 inhibits chronic inflammatory and neuropathic pain via block of Cav3.2 T-type calcium channels and activation of CB2 receptors.
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Additional excerpts
...2 channels (Berger et al., 2014)....
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Cites background from "NMP-7 inhibits chronic inflammatory..."
...More recently, a series of novel DHP derivatives with a condensed hexahydroquinoline 1,4-DHP ring system were identified (Bladen et al., 2014)....
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Cites background from "NMP-7 inhibits chronic inflammatory..."
...2 blocker SNI model analgesic effect (Berger et al., 2014) Suramin and the flavonoid gossypetin USP5-Cav3....
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...2 T-type channel blocker, was shown to mediate a significant analgesic effect in the model of neuropathic pain (Berger et al. , 2014)....
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References
251 citations
"NMP-7 inhibits chronic inflammatory..." refers background in this paper
...Conversely, increased T-type channel activity in the primary pain pathway occurs in models of chronic pain such as spinal nerve injury [25], peripheral nerve injury [26], colonic hypersensitivity [8] and diabetic neuropathy [27]....
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233 citations
"NMP-7 inhibits chronic inflammatory..." refers background in this paper
...knockdown [7,8] or inhibition of the T-type calcium channel by T-type channel modulators produce significant antinociceptive effects in vivo [9-13]....
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...Systemic, peripheral and intrathecal administration of T-type calcium channel blockers such as mibefradil and ethosuximide have been previously shown to reverse mechanical and thermal hypersensitivity in response to nerve injury [11]....
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...Inhibition of T-type channels or in vivo antisense-mediated knockdown produces antinociception in these and other models of chronic pain [7-16]....
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223 citations
"NMP-7 inhibits chronic inflammatory..." refers background in this paper
...2 knockout mouse strains also show attenuated pain responses in the formalin-induced pain model [16]....
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...Inhibition of T-type channels or in vivo antisense-mediated knockdown produces antinociception in these and other models of chronic pain [7-16]....
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203 citations
"NMP-7 inhibits chronic inflammatory..." refers background in this paper
...Conversely, increased T-type channel activity in the primary pain pathway occurs in models of chronic pain such as spinal nerve injury [25], peripheral nerve injury [26], colonic hypersensitivity [8] and diabetic neuropathy [27]....
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192 citations
"NMP-7 inhibits chronic inflammatory..." refers background or result in this paper
...2 channel trafficking mediates analgesia in mouse models of inflammatory and neuropathic pain [17]....
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...In response to CFA, these mice showed similar mechanical withdrawal thresholds relative to wild-type mice (Figure 5), as previously reported [17]....
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