NMP-7 inhibits chronic inflammatory and neuropathic pain via block of Cav3.2 T-type calcium channels and activation of CB2 receptors.
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Additional excerpts
...2 channels (Berger et al., 2014)....
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Cites background from "NMP-7 inhibits chronic inflammatory..."
...More recently, a series of novel DHP derivatives with a condensed hexahydroquinoline 1,4-DHP ring system were identified (Bladen et al., 2014)....
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Cites background from "NMP-7 inhibits chronic inflammatory..."
...2 blocker SNI model analgesic effect (Berger et al., 2014) Suramin and the flavonoid gossypetin USP5-Cav3....
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...2 T-type channel blocker, was shown to mediate a significant analgesic effect in the model of neuropathic pain (Berger et al. , 2014)....
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References
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"NMP-7 inhibits chronic inflammatory..." refers background in this paper
...knockdown [7,8] or inhibition of the T-type calcium channel by T-type channel modulators produce significant antinociceptive effects in vivo [9-13]....
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...Inhibition of T-type channels or in vivo antisense-mediated knockdown produces antinociception in these and other models of chronic pain [7-16]....
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67 citations
"NMP-7 inhibits chronic inflammatory..." refers background in this paper
...Additionally, both Δ(9)-THC and cannabidiol [21] or the endogenous cannabinoid anandamide and its derivatives [20-22] inhibit T-type channel activity....
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"NMP-7 inhibits chronic inflammatory..." refers background in this paper
...The antinociceptive effects of the cannabinoid system make it an attractive target for relief of chronic pain, and randomized-controlled trials have indeed shown that cannabis use results in significant analgesia [18]....
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43 citations
"NMP-7 inhibits chronic inflammatory..." refers background or methods in this paper
...Mouse ambulatory behavior was assessed in an open-field test as described previously [23]....
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...The use of such mixed CB/T-type calcium channel interacting compounds may provide a strategy for the development of better analgesics [23]....
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