Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry
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...For example, autophagy has been shown to be required for formation of spores in yeast (Tsukada and Ohsumi, 1993) and dauer larvae inCaenorhabditis elegans (Meléndez et al., 2003), both of which are triggered by starvation to sustain the organism during adverse conditions....
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...When yeast cells are cultured in nitrogen-free medium, autophagy-deficient cells rapidly decrease intracellular amino acid levels (Onodera and Ohsumi, 2005) and lose their viability (Tsukada and Ohsumi, 1993)....
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"Nod1 and Nod2 direct autophagy by r..." refers background in this paper
...1823" language="eng" relation="no"> Autophagy is a highly conserved, bulk degradation system in which portions of cytoplasm, damaged organelles or long-lived proteins are sequestered into double-membraned structures, called autophagosomes, that eventually deliver their contents for degradation in the lysosomal compartmen...
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"Nod1 and Nod2 direct autophagy by r..." refers background in this paper
...In particular, NOD2 was the first gene associated with susceptibility to Crohn's diseas...
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"Nod1 and Nod2 direct autophagy by r..." refers background in this paper
...Notably, the greater number of GFP-LC3 dots was due to the induction of autophagy rather than to the inhibition of autophagosome maturation, as inhibitors of LC3 turnover, bafilomycin A1 and chloroquin...
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