Nonalcoholic Fatty Liver Disease, the Gut Microbiome, and Diet
Reads0
Chats0
TLDR
Diet, which can modulate the gut microbiome and several metabolic pathways involved in NAFLD development, shows a potential tripartite relation between the gut, diet, and the liver.About:
This article is published in Advances in Nutrition.The article was published on 2017-03-01 and is currently open access. It has received 111 citations till now. The article focuses on the topics: Liver disorder & Nonalcoholic fatty liver disease.read more
Citations
More filters
Journal ArticleDOI
Butyrate: A Double-Edged Sword for Health?
TL;DR: The present knowledge on the properties of butyrate, especially its potential effects and mechanisms involved in intestinal health and obesity, are summarized.
Journal ArticleDOI
Intestinal Microbiome Shifts, Dysbiosis, Inflammation, and Non-alcoholic Fatty Liver Disease.
TL;DR: It is hypothesized that disruption of the intestinal–mucosal macrophage interface is a key factor in intestinal-liver axis disturbances and the incorporation of evidence based probiotic/prebiotic formulations as adjunctive modalities may enhance lifestyle modification management strategies for the amelioration of NAFLD.
Journal ArticleDOI
Prebiotic and probiotic treatment of nonalcoholic fatty liver disease: a systematic review and meta-analysis.
TL;DR: A meta-analysis supports the potential use of microbial therapies in the treatment of NAFLD and sheds light on their potential mode of action.
Journal ArticleDOI
Curcumin and inflammation in non-alcoholic fatty liver disease: a randomized, placebo controlled clinical trial.
Saeede Saadati,Amir Sadeghi,Asieh Mansour,Zahra Yari,Hossein Poustchi,Mehdi Hedayati,Behzad Hatami,Azita Hekmatdoost +7 more
TL;DR: The results indicated that curcumin supplementation plus lifestyle modification is not superior to lifestyle modification alone in amelioration of inflammation.
Journal ArticleDOI
Interactions between gut microbiota and non-alcoholic liver disease: The role of microbiota-derived metabolites.
Yufang Ding,Karin Yanagi,Clint Cheng,Robert C. Alaniz,Kyongbum Lee,Arul Jayaraman,Arul Jayaraman +6 more
TL;DR: It is revealed that the metabolites can both agonize and antagonize their cognate receptors to reduce or exacerbate liver steatosis and inflammation, and that the effects are metabolite‐ and context‐specific.
References
More filters
Journal ArticleDOI
An obesity-associated gut microbiome with increased capacity for energy harvest
Peter J. Turnbaugh,Ruth E. Ley,Michael A. Mahowald,Vincent Magrini,Elaine R. Mardis,Jeffrey I. Gordon +5 more
TL;DR: It is demonstrated through metagenomic and biochemical analyses that changes in the relative abundance of the Bacteroidetes and Firmicutes affect the metabolic potential of the mouse gut microbiota and indicates that the obese microbiome has an increased capacity to harvest energy from the diet.
Journal ArticleDOI
Diversity of the human intestinal microbial flora.
Paul B. Eckburg,Elisabeth M. Bik,Charles N. Bernstein,Elizabeth Purdom,Les Dethlefsen,Michael Sargent,Steven R. Gill,Karen E. Nelson,David A. Relman,David A. Relman,David A. Relman +10 more
TL;DR: A majority of the bacterial sequences corresponded to uncultivated species and novel microorganisms, and significant intersubject variability and differences between stool and mucosa community composition were discovered.
Journal ArticleDOI
Enterotypes of the human gut microbiome
Manimozhiyan Arumugam,Jeroen Raes,Eric Pelletier,Denis Le Paslier,Takuji Yamada,Daniel R. Mende,Gabriel Fernandes,Julien Tap,Thomas Brüls,Jean-Michel Batto,Marcelo Bertalan,Natalia Borruel,Francesc Casellas,Leyden Fernández,Laurent Gautier,Torben Hansen,Masahira Hattori,Tetsuya Hayashi,Michiel Kleerebezem,Ken Kurokawa,Marion Leclerc,Florence Levenez,Chaysavanh Manichanh,H. Bjørn Nielsen,Trine Nielsen,Nicolas Pons,Julie Poulain,Junjie Qin,Thomas Sicheritz-Pontén,Sebastian Tims,David Torrents,Edgardo Ugarte,Erwin G. Zoetendal,Jun Wang,Francisco Guarner,Oluf Pedersen,Willem M. de Vos,Søren Brunak,Joël Doré,Jean Weissenbach,S. Dusko Ehrlich,Peer Bork +41 more
TL;DR: Three robust clusters (referred to as enterotypes hereafter) are identified that are not nation or continent specific and confirmed in two published, larger cohorts, indicating that intestinal microbiota variation is generally stratified, not continuous.
Journal ArticleDOI
The gut microbiota as an environmental factor that regulates fat storage
Fredrik Bäckhed,Hao Ding,Hao Ding,Ting Wang,Lora V. Hooper,Gou Young Koh,Andras Nagy,Clay F. Semenkovich,Jeffrey I. Gordon +8 more
TL;DR: In this article, the authors found that conventionalization of adult germ-free C57BL/6 mice with a normal microbiota harvested from the distal intestine (cecum) of conventionally raised animals produces a 60% increase in body fat content and insulin resistance within 14 days despite reduced food intake.
Journal ArticleDOI
Linking Long-Term Dietary Patterns with Gut Microbial Enterotypes
Gary D. Wu,Jun Chen,Christian Hoffmann,Christian Hoffmann,Kyle Bittinger,Ying-Yu Chen,Sue A. Keilbaugh,Meenakshi Bewtra,Dan Knights,William A. Walters,Rob Knight,Rohini Sinha,Erin Gilroy,Kernika Gupta,Robert N. Baldassano,Lisa Nessel,Hongzhe Li,Frederic D. Bushman,James D. Lewis +18 more
TL;DR: Alternative enterotype states are associated with long-term diet, particularly protein and animal fat (Bacteroides) versus carbohydrates (Prevotella) and other enterotypes distinguished primarily by levels of Bacteroide and Prevotella.