Journal ArticleDOI
Noninvasive determination of local cerebral metabolic rate of glucose in man
Reads0
Chats0
TLDR
The rate constants of FDG in man were found to be comparable to those of deoxyglucose in rat and in rhesus monkey and the subject-to-subject variation of LCMRGlc as measured by the present method was comparable to that of other methods that measure whole-brain CMRglc.Abstract:
A method for the determination of local cerebral metabolic rates of glucose (LCMRGlc) in normal man is described. The method employs [18F]2-fluoro-2-deoxy-D-glucose (FDG) and emission-computed tomography (ECT). FDG was injected intravenously as a bolus. Radioactivities in separate brain regions were measured with ECT. Plasma FDG concentration following injection was measured from blood samples. A mathematical model that describes the kinetics of FDG transports was employed to determine the transport rate constants of FDG and to convert the radioactivity measurements to metabolic rates. The model has taken into account the possible dephosphorylation reaction from FDG-6-PO4 (FDG-6-P) to free FDG in brain tissues. Experiments were performed in 13 normal volunteers. The rate constants of FDG in man were found to be comparable to those of deoxyglucose in rat and in rhesus monkey. The average LCMRGlc in gray and in white matter were found to be 7.30 +/- 1.18 (SD) and 3.41 +/- 0.64 mg/min per 100 g brain tissue, respectively. The subject-to-subject variation of LCMRGlc as measured by the present method was comparable to those of other methods that measure whole-brain CMRGlc.read more
Citations
More filters
Journal Article
Blood Flow, Oxygen and Nutrient Supply, and Metabolic Microenvironment of Human Tumors: A Review
TL;DR: Current knowledge of blood flow and perfusion-related parameters, which usually go hand in hand and in turn define the cellular metabolic microenvironment of human malignancies, are summarized for predicting the acute and/or long-term response of tumors to therapy.
Journal ArticleDOI
Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM.
TL;DR: Apres l'ingestion de glucose, l'insulino-secretion du pancreas est stimulee et la combinaison de l'hyperglycemie et de l-hyperinsulinemie doit induire la captation de glucose dans les territoires splanchique et peripherique (muscles) and the suppression of the production hepatique du glucose.
Journal ArticleDOI
Pathogenesis of NIDDM: A balanced overview
TL;DR: Information concerning the loss of first-phase insulin secretion, altered pulsatility of insulin release, and enhanced proinsulin-insulin secretory ratio is discussed as it pertains to altered β-cell function in NIDDM.
Journal ArticleDOI
Reduction of prefrontal cortex glucose metabolism common to three types of depression.
Lewis R. Baxter,Jeffrey M. Schwartz,Michael E. Phelps,John C. Mazziotta,Barry H. Guze,Carl Selin,Robert H. Gerner,Ron M. Sumida +7 more
TL;DR: Using positron emission tomography, cerebral glucose metabolism in drug-free, age- and sex-matched, right-handed patients with unipolar depression, bipolar depression, obsessive-compulsive disorder (OCD) with secondary depression, OCD without major depression, and normal controls is studied.
References
More filters
Journal ArticleDOI
The [14C]deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure, and normal values in the conscious and anesthetized albino rat.
Louis Sokoloff,Martin Reivich,Charles Kennedy,Charles Kennedy,M. H. Des Rosiers,Clifford S. Patlak,Karen D. Pettigrew,O. Sakurada,M. Shinohara +8 more
TL;DR: The method can be applied to most laboratory animals in the conscious state and is based on the use of 2‐deoxy‐D‐[14C]glucose as a tracer for the exchange of glucose between plasma and brain and its phosphorylation by hexokinase in the tissues.
Journal ArticleDOI
Tomographic measurement of local cerebral glucose metabolic rate in humans with (F-18)2-fluoro-2-deoxy-D-glucose: validation of method.
Michael E. Phelps,Michael E. Phelps,Sung-Cheng Huang,Sung-Cheng Huang,Edward J. Hoffman,Edward J. Hoffman,Carl Selin,Carl Selin,L. Sokoloff,L. Sokoloff,David E. Kuhl,David E. Kuhl +11 more
TL;DR: The data indicate that cerebral FDG‐6‐PO4 in humans increases for about 90 minutes, plateaus, and then slowly decreases, and that cerebral blood FDG activity levels were found to be a minor fraction of tissue activity.
Journal ArticleDOI
Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection
TL;DR: Saturability of D-glucose uptake was demonstrated and evidence presented that all of the five hexoses measurably taken up by brain shared a common carrier, two blood-brain barrier carrier systems for amino acids.
Journal ArticleDOI
The [18F]fluorodeoxyglucose method for the measurement of local cerebral glucose utilization in man.
Martin Reivich,David E. Kuhl,Alfred P. Wolf,Joel H. Greenberg,Michael E. Phelps,T. Ido,V Casella,Joanna S. Fowler,Eric A. Hoffman,Abass Alavi,Peter M. Som,L. Sokoloff +11 more
TL;DR: A mathematical model and derived operational equation are used which enable local cerebral glucose consumption to be calculated in terms of the following measurable variables: gray matter, white matter, and whole brain metabolic rates, calculated as a weighted average based on the approximate volume of each structure.
Journal ArticleDOI
Tomographic measurement of local cerebral glucose metabolic rate in humans with (f-18)2-fluoro-2-deoxy-d-glucose: validation of method
TL;DR: The data indicate that cerebral FDG-6-PO4 in humans increases for about 90 minutes, plateaus, and then slowly decreases, and that cerebral blood FDG activity levels were found to be a minor fraction of tissue activity.