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Nonsteroidal antiinflammatory agents. I. 6-substituted 2-naphthylacetic acids
Ian T. Harrison,Brian. Lewis,Peter H. Nelson,Wendell H. Rooks,A. P. Roszkowski,Albert J. Tomolonis,John H Fried +6 more
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This article is published in Journal of Medicinal Chemistry.The article was published on 1970-03-01. It has received 229 citations till now.read more
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Large-scale oxidations in the pharmaceutical industry.
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The metabolic chiral inversion and dispositional enantioselectivity of the 2-arylpropionic acids and their biological consequences.
TL;DR: The biological consequences of the metabolic chiral inversion and enantioselective disposition of the 2-arylpropionates have been summarized in terms of their implications for the development and use of safer and more effective drugs of this class.
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Glycolamide Esters as Biolabile Prodrugs of Carboxylic Acid Agents: Synthesis, Stability, Bioconversion, and Physicochemical Properties
TL;DR: Esters of N,N-disubstituted glycolamides are suggested to be a useful biolabile prodrug type for several carboxylic acid agents because they combine a high susceptibility to undergo enzymatic hydrolysis in plasma with a high stability in aqueous solution.
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Tetrahedron report number 205
Journal ArticleDOI
Enzymes in the synthesis of chiral drugs.
TL;DR: The use of enzymes in the synthesis and modification of optically pure drugs is reviewed, with special attention on the synthesis of new pharmaceuticals which may require efficient procedures for large-scale synthesis in the future.