Normal skin and hypertrophic scar fibroblasts differentially regulate collagen and fibronectin expression as well as mitochondrial membrane potential in response to basic fibroblast growth factor.
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69 citations
Cites background from "Normal skin and hypertrophic scar f..."
...Perhaps not surprisingly, the proliferative capacity of fibroblasts from hypertrophic scars is greater than that of normal skin.(24) However, compared with normal skin and hypertrophic scars, keloid fibroblasts possess higher proliferating cell nuclear antigen expression and display apoptosis resistance....
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Cites background from "Normal skin and hypertrophic scar f..."
...For example, HTSFs reportedly have a myofibroblast-like character [27]; high levels of TGF-β1 and its receptors; elevated expression of growth factors and inflammatory cytokines, such as CTGF, IL-6, and IL-8; and, Figure 7....
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...HTSFs reportedly have a myofibroblast-like character [27]; high levels of TGF-β1 and its receptors; elevated expression of growth factors and inflammatory cytokines, such as CTGF, IL-6, and IL-8; and, increased ECM components as fibronectin and collagen [28]....
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42 citations
References
33 citations
"Normal skin and hypertrophic scar f..." refers background in this paper
...In addition, mitochondria may be an important mediator in extracellular matrix homeostasis and cell proliferation (11-13)....
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"Normal skin and hypertrophic scar f..." refers background in this paper
...Fibronectin is also highly up-regulated after wound healing and acts as a provisional matrix, promoting fibroblast migration in the early phase of wound healing (28,29)....
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"Normal skin and hypertrophic scar f..." refers background in this paper
...Excessive deposition of fibronectin may contribute, at least in part, to hypertrophic scar formation (30)....
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Additional excerpts
...The reduction of type I collagen production was also observed under immunofluorescent and scanning electron microscopy after administration of bFGF for 6 weeks (24)....
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