Normal telomere length and chromosomal end capping in poly(ADP-ribose) polymerase–deficient mice and primary cells despite increased chromosomal instability
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...Furthermore, mice deficient in Tankyrase1 or Tankyrase2 have normal telomeres over multiple generations [35,98,99], and while some investigators report telomere shortening and other telomere aberrations in PARP-deficient mice [56,91,93], others have been unable to detect telomere defects [55,92,100]....
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22 citations
22 citations
Cites background from "Normal telomere length and chromoso..."
...…DBD transgenics show severe defects in single strand break repair and elevated sister chromatid exchange (Beneke et al., 2000; Conde et al., 2001; Samper et al., 2001) the development of spontaneous tumors has never been observed in these mouse mutants (data shown here and Wang et al., 1995;…...
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22 citations
21 citations
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"Normal telomere length and chromoso..." refers methods in this paper
...As control for the two-hybrid assay we show interaction between the cell cycle proteins CDK4 and p16 as described previously (Table VI; Serrano et al., 1993)....
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"Normal telomere length and chromoso..." refers background or methods in this paper
...These Robertsonian fusions are different from those found in late generation telomerase-deficient mice that have critically short telomeres (Blasco et al., 1997)....
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...5 embryos derived from heterozygous crosses as described (Blasco et al., 1997)....
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...Telomeres have an essential role in chromosome stability and are proposed to be biological determinants in the processes of tumorigenesis and aging (for reviews see Blackburn, 1991; Autexier and Greider, 1996; Greider, 1996; Blasco et al., 1997; Lee et al., 1998)....
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...Then the plugs were digested with MboI overnight and run in a pulse field gel electrophoresis as described (Blasco et al., 1997)....
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1,923 citations
"Normal telomere length and chromoso..." refers background in this paper
...Vertebrate telomeres consist of tandem repeats of the sequence TTAGGG (for review see Blackburn, 1991)....
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...Telomeres have an essential role in chromosome stability and are proposed to be biological determinants in the processes of tumorigenesis and aging (for reviews see Blackburn, 1991; Autexier and Greider, 1996; Greider, 1996; Blasco et al., 1997; Lee et al., 1998)....
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