Normal telomere length and chromosomal end capping in poly(ADP-ribose) polymerase–deficient mice and primary cells despite increased chromosomal instability
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Cites background from "Normal telomere length and chromoso..."
...Despite a tight inhibitory control of DDR at telomeres, mammalian chromosome ends are nevertheless a physiological substrate of the DDR apparatus as the inactivation of genes encoding certain DDR factors involved in DSB repair such as DNA-PK [26-30], Parp-1 [31,32], Rad51D [33] and Wrn [34], as well as components of the AtmMrell/Rad50/Nbsl pathway [35-38] results in telomere dysfunction....
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...Despite a tight inhibitory control of DDR at telomeres, mammalian chromosome ends are nevertheless a physiological substrate of the DDR apparatus as the inactivation of genes encoding certain DDR factors involved in DSB repair such as DNA-PK [26-30], Parp-1 [31,32], Rad51D [33] and Wrn [34], as well as components of the AtmMrell/Rad50/Nbsl pathway [35-38] results in telomere dysfunction....
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12 citations
11 citations
Cites background from "Normal telomere length and chromoso..."
...Given that both telomere shortening and/or inflammationrelated generation of oxygen and/or nitrogen species are phenomena that have been associated with an increased frequency of acquired chromosomal abnormalities [13,14,15,16,17,18,19], we hypothesize that an alternative or additional biological effect of stress could be the acquisition of somatic cell chromosomal instability....
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8 citations
8 citations
References
3,716 citations
"Normal telomere length and chromoso..." refers methods in this paper
...As control for the two-hybrid assay we show interaction between the cell cycle proteins CDK4 and p16 as described previously (Table VI; Serrano et al., 1993)....
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2,066 citations
"Normal telomere length and chromoso..." refers background or methods in this paper
...These Robertsonian fusions are different from those found in late generation telomerase-deficient mice that have critically short telomeres (Blasco et al., 1997)....
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...5 embryos derived from heterozygous crosses as described (Blasco et al., 1997)....
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...Telomeres have an essential role in chromosome stability and are proposed to be biological determinants in the processes of tumorigenesis and aging (for reviews see Blackburn, 1991; Autexier and Greider, 1996; Greider, 1996; Blasco et al., 1997; Lee et al., 1998)....
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...Then the plugs were digested with MboI overnight and run in a pulse field gel electrophoresis as described (Blasco et al., 1997)....
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1,923 citations
"Normal telomere length and chromoso..." refers background in this paper
...Vertebrate telomeres consist of tandem repeats of the sequence TTAGGG (for review see Blackburn, 1991)....
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...Telomeres have an essential role in chromosome stability and are proposed to be biological determinants in the processes of tumorigenesis and aging (for reviews see Blackburn, 1991; Autexier and Greider, 1996; Greider, 1996; Blasco et al., 1997; Lee et al., 1998)....
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