Notch-1 induces Epithelial-mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells
Bin Bao,Zhiwei Wang,Shadan Ali,Dejuan Kong,Yiwei Li,Aamir Ahmad,Sanjeev Banerjee,Asfar S. Azmi,Lucio Miele,Fazlul H. Sarkar +9 more
Reads0
Chats0
TLDR
The results suggest that the activation of Notch-1 signaling contributes to the acquisition of EMT phenotype, which is in part mediated through the regulation of miR-200b and CSC self-renewal capacity, and these processes could be attenuated by genistein treatment.About:
This article is published in Cancer Letters.The article was published on 2011-08-01 and is currently open access. It has received 285 citations till now. The article focuses on the topics: Cancer stem cell & Epithelial–mesenchymal transition.read more
Citations
More filters
Journal ArticleDOI
New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer
TL;DR: It is highlighted how EMT gives rise to a variety of intermediate cell states between the epithelial and the mesenchymal state which could function as cancer stem cells, and its effects on the immunobiology of carcinomas.
Journal ArticleDOI
Metformin inhibits cell proliferation, migration and invasion by attenuating CSC function mediated by deregulating miRNAs in pancreatic cancer cells
Bin Bao,Zhiwei Wang,Shadan Ali,Aamir Ahmad,Asfar S. Azmi,Sanila H. Sarkar,Sanjeev Banerjee,Dejuan Kong,Yiwei Li,Shivam Thakur,Fazlul H. Sarkar +10 more
TL;DR: It is found that metformin significantly decreased cell survival, clonogenicity, wound-healing capacity, sphere-forming capacity (pancreatospheres), and increased disintegration of pancreatospheres in both gemcitabine-sensitive and gemcitABine-resistant pancreatic cancer cells.
Journal ArticleDOI
Curcumin Analogue CDF Inhibits Pancreatic Tumor Growth by Switching on Suppressor microRNAs and Attenuating EZH2 Expression
Bin Bao,Shadan Ali,Sanjeev Banerjee,Zhiwei Wang,Farah Logna,Asfar S. Azmi,Dejuan Kong,Aamir Ahmad,Yiwei Li,Subhash Padhye,Fazlul H. Sarkar +10 more
TL;DR: Results indicated that diflourinated-curcumin inhibited pancreatic cancer tumor growth and aggressiveness by targeting an EZH2-miRNA regulatory circuit for epigenetically controlled gene expression.
Journal ArticleDOI
DCLK1 Marks a Morphologically Distinct Subpopulation of Cells With Stem Cell Properties in Preinvasive Pancreatic Cancer
Jennifer M. Bailey,Janivette Alsina,Zeshaan A. Rasheed,Florencia McAllister,Ya-Yuan Fu,Ruben Plentz,Ruben Plentz,Hao Zhang,Pankaj J. Pasricha,Nabeel Bardeesy,William Matsui,Anirban Maitra,Steven D. Leach +12 more
TL;DR: Human PDAC cells and pancreatic neoplasms in mice contain morphologically and functionally distinct subpopulations that have cancer stem cell-like properties that can be identified at the earliest stages of pancreatic tumorigenesis and provide new cellular and molecular targets for pancreatic cancer treatment and/or chemoprevention.
Journal ArticleDOI
Overview of cancer stem cells (CSCs) and mechanisms of their regulation: implications for cancer therapy.
TL;DR: These findings suggest that CSCs may represent novel therapeutic targets for the treatment and/or prevention of tumor progression, since they appear to be involved in cell migration, invasion, metastasis, and treatment resistance–all of which lead to poor clinical outcomes.
References
More filters
Journal ArticleDOI
Global cancer statistics
TL;DR: A substantial proportion of the worldwide burden of cancer could be prevented through the application of existing cancer control knowledge and by implementing programs for tobacco control, vaccination, and early detection and treatment, as well as public health campaigns promoting physical activity and a healthier dietary intake.
Journal ArticleDOI
Global cancer statistics, 2002.
TL;DR: There are striking variations in the risk of different cancers by geographic area, most of the international variation is due to exposure to known or suspected risk factors related to lifestyle or environment, and provides a clear challenge to prevention.
Journal ArticleDOI
Cancer statistics, 2010
TL;DR: The American Cancer Society as mentioned in this paper estimated the number of new cancer cases and deaths expected in the United States in the current year and compiles the most recent data regarding cancer incidence, mortality, and survival based on incidence data from the National Cancer Institute, the Centers for Disease Control and Prevention, and the North American Association of Central Cancer Registries and mortality data from National Center for Health Statistics.
Journal ArticleDOI
Epithelial-Mesenchymal Transition: At the Crossroads of Development and Tumor Metastasis
Jing Yang,Robert A. Weinberg +1 more
TL;DR: This review summarizes and compares major signaling pathways that regulate the epithelial-mesenchymal transitions during both development and tumor metastasis and examines their role in carcinoma invasion and metastasis.