Notch Inhibitors for Cancer Treatment
Ingrid Espinoza,Lucio Miele +1 more
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TLDR
The basics of Notch signaling and the role of notch in normal and cancer stem cells are described as a logic way to develop different Notch inhibitors and their current stage of progress for cancer patient's treatment.About:
This article is published in Pharmacology & Therapeutics.The article was published on 2013-08-01 and is currently open access. It has received 253 citations till now. The article focuses on the topics: Notch signaling pathway & Hes3 signaling axis.read more
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Journal ArticleDOI
Targeting Notch, Hedgehog, and Wnt pathways in cancer stem cells: clinical update
Naoko Takebe,Lucio Miele,Pamela Jo Harris,Woondong Jeong,Hideaki Bando,Michael Kahn,Sherry X. Yang,S. Percy Ivy +7 more
TL;DR: An update on the latest advances in the clinical development of treatment strategies targeting cancer stem cells with rational combinations of agents to inhibit possible compensatory escape mechanisms is provided.
Journal ArticleDOI
Targeting cancer stem cell pathways for cancer therapy
Liqun Yang,Pengfei Shi,Gaichao Zhao,Jie Xu,Wen Peng,Jiayi Zhang,Guanghui Zhang,Xiaowen Wang,Zhen Dong,Fei Chen,Hongjuan Cui +10 more
TL;DR: Molecules, vaccines, antibodies, and CAR-T (chimeric antigen receptor T cell) cells have been developed to specifically target CSCs, and some of these factors are already undergoing clinical trials.
Journal ArticleDOI
Pancancer survival analysis of cancer hallmark genes
TL;DR: In this article, the authors estimate the prognostic effect of established cancer hallmark genes in multiple distinct cancer types using RNA-seq HTSeq counts and survival data from 26 different tumor types acquired from the TCGA repository.
Journal ArticleDOI
A DLL3-targeted antibody-drug conjugate eradicates high-grade pulmonary neuroendocrine tumor-initiating cells in vivo
Laura Saunders,Alexander J. Bankovich,Wade C. Anderson,Monette Aujay,Sheila Bheddah,KristenAnn Black,Desai Radhika Chetan,Paul Anthony Escarpe,Johannes Hampl,Amy Laysang,David R. Liu,Javier Lopez-Molina,Milly Milton,Albert Park,Marybeth A. Pysz,Hui Shao,Brian Slingerland,Torgov Michael,Samuel A. Williams,Orit Foord,Howard Philip Wilson,Jacek Jassem,Andrzej Badzio,Piotr Czapiewski,David H. Harpole,Afshin Dowlati,Pierre P. Massion,William D. Travis,M. Catherine Pietanza,M. Catherine Pietanza,John T. Poirier,John T. Poirier,Charles M. Rudin,Robert A. Stull,Scott J. Dylla +34 more
TL;DR: The authors targeted DLL3 with an antibody conjugated to a cytotoxic drug, which proved to be much more effective than standard chemotherapy for treating patient-derived tumor xenografts and is a promising first-in-class ADC for the treatment of high-grade pulmonary neuroendocrine tumors.
Posted ContentDOI
Pancancer survival analysis of cancer hallmark genes
TL;DR: The aim of this study was to estimate the prognostic effect of the established cancer hallmark genes in multiple distinct cancer types and to help to prioritize future targeted therapy development in different types of solid tumors.
References
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Journal ArticleDOI
The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism
TL;DR: This Review highlights recent studies in Notch signaling that reveal new molecular details about the regulation of ligand-mediated receptor activation, receptor proteolysis, and target selection.
Journal ArticleDOI
Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia
Andrew P. Weng,Andrew P. Weng,Adolfo A. Ferrando,Adolfo A. Ferrando,Woojoong Lee,Woojoong Lee,John P. Morris,John P. Morris,Lewis B. Silverman,Lewis B. Silverman,Cheryll Sanchez-Irizarry,Cheryll Sanchez-Irizarry,Stephen C. Blacklow,Stephen C. Blacklow,A. Thomas Look,A. Thomas Look,Jon C. Aster,Jon C. Aster +17 more
TL;DR: These findings greatly expand the role of activated NOTCH1 in the molecular pathogenesis of human T-ALL and provide a strong rationale for targeted therapies that interfere with NOTCH signaling.
Journal ArticleDOI
TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms.
Leif W. Ellisen,Jeffrey Bird,Daniel C. West,A. Lee Soreng,Thomas C. Reynolds,Stephen D. Smith,Jeffrey Sklar +6 more
TL;DR: It is shown that the locus on chromosome 9 contains a gene highly homologous to the Drosophila gene Notch, which may be important for normal lymphocyte function and that alteration of TAN-1 may play a role in the pathogenesis of some T cell neoplasms.
Journal ArticleDOI
Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain.
TL;DR: It is shown that signalling by a constitutively active membrane-bound Notch-1 protein requires the proteolytic release of the Notch intracellular domain (NICD), which interacts preferentially with CSL.
Journal ArticleDOI
Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1
Nishant Agrawal,Mitchell J. Frederick,Curtis R. Pickering,Chetan Bettegowda,Kyle Chang,Ryan J. Li,Carole Fakhry,Tong Xin Xie,Jiexin Zhang,Jing Wang,Nianxiang Zhang,Adel K. El-Naggar,Samar A. Jasser,John N. Weinstein,Lisa R. Trevino,Jennifer Drummond,Donna M. Muzny,Yuanqing Wu,Laura D. Wood,Ralph H. Hruban,William H. Westra,Wayne M. Koch,Joseph A. Califano,Joseph A. Califano,Richard A. Gibbs,Richard A. Gibbs,David Sidransky,Bert Vogelstein,Victor E. Velculescu,Nickolas Papadopoulos,David A. Wheeler,Kenneth W. Kinzler,Jeffrey N. Myers +32 more
TL;DR: To explore the genetic origins of head and neck squamous cell carcinoma, whole-exome sequencing and gene copy number analyses were used to study 32 primary tumors and identified mutations in FBXW7 and NotCH1, suggesting that NOTCH1 may function as a tumor suppressor gene rather than an oncogene in this tumor type.
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Notch Signaling: Cell Fate Control and Signal Integration in Development
The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism
Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia
Andrew P. Weng,Andrew P. Weng,Adolfo A. Ferrando,Adolfo A. Ferrando,Woojoong Lee,Woojoong Lee,John P. Morris,John P. Morris,Lewis B. Silverman,Lewis B. Silverman,Cheryll Sanchez-Irizarry,Cheryll Sanchez-Irizarry,Stephen C. Blacklow,Stephen C. Blacklow,A. Thomas Look,A. Thomas Look,Jon C. Aster,Jon C. Aster +17 more