Novel anticancer therapeutics targeting telomerase.
Maria Ruden,Neelu Puri +1 more
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TLDR
The most promising current telomerase targeting therapeutics are the antisense oligonucleotide inhibitor GRN163L and immunotherapies that use dendritic cells (GRVAC1), hTERT peptide (GV1001) or cryptic peptides (Vx-001).About:
This article is published in Cancer Treatment Reviews.The article was published on 2013-08-01 and is currently open access. It has received 307 citations till now. The article focuses on the topics: Telomerase reverse transcriptase & Telomerase.read more
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Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma
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Coumarins as anticancer agents: A review on synthetic strategies, mechanism of action and SAR studies
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Upregulating mutations in the TERT promoter commonly occur in adult malignant gliomas and are strongly associated with total 1p19q loss
Hideyuki Arita,Yoshitaka Narita,Shintaro Fukushima,Kensuke Tateishi,Yuko Matsushita,Akihiko Yoshida,Yasuji Miyakita,Makoto Ohno,V. Peter Collins,Nobutaka Kawahara,Soichiro Shibui,Koichi Ichimura +11 more
TL;DR: The data indicate that mutation of the TERT promoter is one of the major mechanisms of telomerase activation in gliomas, and suggests that they play distinct roles in the pathogenesis of oligodendroglial and astrocytic tumors.
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TERT promoter mutations in bladder cancer affect patient survival and disease recurrence through modification by a common polymorphism
P. Sivaramakrishna Rachakonda,Ismail Hosen,Petra J. de Verdier,Mahdi Fallah,Barbara Heidenreich,Charlotta Ryk,N. Peter Wiklund,Gunnar Steineck,Gunnar Steineck,Dirk Schadendorf,Kari Hemminki,Kari Hemminki,Rajesh Kumar +12 more
TL;DR: It is shown that the telomerase reverse transcriptase (TERT) promoter mutations, which create de novo E-twenty six/ternary complex factors (Ets/TCF) transcription binding sites, influence both survival and recurrence in bladder cancer patients.
References
More filters
Journal ArticleDOI
TRF2 Protects Human Telomeres from End-to-End Fusions
TL;DR: It is shown that the human telomeric protein TRF2 plays a key role in the protective activity of telomeres, and the results raise the possibility that chromosome end fusions and senescence in primary human cells may be caused by loss byTRF2 from shortenedtelomeres.
Journal ArticleDOI
Tankyrase, a Poly(ADP-Ribose) Polymerase at Human Telomeres
TL;DR: Tankyrase, a protein with homology to ankyrins and to the catalytic domain of poly(adenosine diphosphate-ribose) polymerase (PARP), was identified and localized to human telomeres.
Journal ArticleDOI
Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging.
TL;DR: Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging is traced.
Journal ArticleDOI
Telomeres and telomerase in cancer.
TL;DR: The role of telomeres and telomerase is covered in the biology of normal tissue stem/progenitor cells and in the development of cancer to uncover the underlying mechanisms driving genome instability in cancer.
Journal ArticleDOI
Telomerase and cancer therapeutics
TL;DR: The prospect of adding telomerase-based therapies to the growing list of new anticancer products is promising, but what are the advantages and limitations of different approaches, and which patients are the most likely to respond?
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