Journal ArticleDOI
Novel behavioural characteristics of female APPSwe/PS1ΔE9 double transgenic mice
David Cheng,David Cheng,Jac Kee Low,Warren Logge,Brett Garner,Brett Garner,Tim Karl,Tim Karl +7 more
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TLDR
The cheeseboard is presented as a valid alternative to other established spatial memory tests and the task-dependency of some of the findings suggests that behavioural profiling of APPxPS1 transgenic mice should be assessed using a variety of behavioural paradigms.About:
This article is published in Behavioural Brain Research.The article was published on 2014-03-01. It has received 50 citations till now. The article focuses on the topics: Morris water navigation task & Elevated plus maze.read more
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Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models.
Scott J. Webster,Adam D. Bachstetter,Peter T. Nelson,Frederick A. Schmitt,Linda J. Van Eldik +4 more
TL;DR: This review discusses how behavioral tests in mice relate to the pathological and neuropsychological features seen in human Alzheimer's disease, and presents a comprehensive analysis of the temporal progression of behavioral impairments in commonly used AD mouse models that contain mutations in amyloid precursor protein (APP).
Journal ArticleDOI
Assessment of disease-related cognitive impairments using the novel object recognition (NOR) task in rodents.
TL;DR: The novel object recognition test (NOR) test is a two trial cognitive paradigm that assesses recognition memory that is used in rodents for investigating deficits in a variety of animal models of human conditions where cognition is impaired and for testing the efficacy of novel therapeutic agents.
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Subtle behavioral changes and increased prefrontal-hippocampal network synchronicity in APPNL-G-F mice before prominent plaque deposition.
Amira Latif-Hernandez,Disha Shah,Kathleen Craessaerts,Takaomi C. Saido,Takashi Saito,Bart De Strooper,Annemie Van der Linden,Rudi D'Hooge +7 more
TL;DR: Assessment confirmed that behavior at these early ages was largely unaffected in these mice in accordance with previous reports, with some subtle behavioral changes, mainly in social and anxiety‐related test performance.
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Distinguishing normal brain aging from the development of Alzheimer's disease: inflammation, insulin signaling and cognition
Paul Denver,Paula McClean +1 more
TL;DR: The difficulties with discerning normal, age-related cognitive decline with that related to AD are discussed and some neuropathological features of AD and aging are discussed, including amyloid and tau pathology, synapse loss, inflammation and insulin signaling in the brain, with a view to highlighting cognitive or neuropathology markers that distinguish AD from normal aging.
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Inflammation, insulin signaling and cognitive function in aged APP/PS1 mice
TL;DR: The results suggest that normal aging may be associated with enhanced neuroinflammation, oxidative stress, and cognitive decline, however distinctions are apparent in the brain of APP/PS1 mice in terms of inflammation and insulin signaling and in certain cognitive domains.
References
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Journal ArticleDOI
Place navigation impaired in rats with hippocampal lesions.
TL;DR: It is reported that, in addition to a spatial discrimination impairment, total hippocampal lesions also cause a profound and lasting placenavigational impairment that can be dissociated from correlated motor, motivational and reinforcement aspects of the procedure.
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The Global Deterioration Scale for assessment of primary degenerative dementia.
TL;DR: The authors describe a Global Deterioration Scale for the assessment of primary degenerative dementia and delineation of its stages and have used it successfully for more than 5 years and validated it against behavioral, neuroanatomic, and neurophysiologic measures in patients with primary degeneratives dementia.
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Pathways towards and away from Alzheimer's disease
TL;DR: Rapid progress towards understanding the cellular and molecular alterations that are responsible for the neuron's demise may soon help in developing effective preventative and therapeutic strategies in Alzheimer's disease.
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Mutant presenilins specifically elevate the levels of the 42 residue β-amyloid peptide in vivo: evidence for augmentation of a 42-specific γ secretase
Joanna L. Jankowsky,Joanna L. Jankowsky,Daniel J. Fadale,Jeffrey Anderson,Guilian Xu,Victoria Gonzales,Nancy A. Jenkins,Neal G. Copeland,Michael K. Lee,Linda H. Younkin,Steven L. Wagner,Steven G. Younkin,David R. Borchelt +12 more
TL;DR: A direct correlation between the concentration of Aβ42 and the rate of amyloid deposition is demonstrated and suggests that PS1 variants do not simply alter the preferred cleavage site for γ-secretase, but rather that they have more complex effects on the regulation of ιsecretase and its access to substrates.
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Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice
Sheryl S. Moy,Jessica J. Nadler,Antonio Perez,Ryan P. Barbaro,Josephine M. Johns,Terry Magnuson,Terry Magnuson,Joseph Piven,Jacqueline N. Crawley,Jacqueline N. Crawley +9 more
TL;DR: A new standardized procedure to quantitate sociability and preference for social novelty in mice provides a method to assess tendencies for social avoidance in mouse models of autism.