Novel construction of polycyclic systems fused to cyclobutane by tandem intramolecular Michael-Aldol reaction
01 May 1992-Journal of the American Chemical Society (American Chemical Society)-Vol. 114, Iss: 11, pp 4408-4410
About: This article is published in Journal of the American Chemical Society.The article was published on 1992-05-01. It has received 40 citations till now. The article focuses on the topics: Aldol condensation & Aldol reaction.
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TL;DR: This paper aims to demonstrate the efforts towards in-situ applicability of EMMARM, which aims to provide real-time information about the “building blocks” of EMT and its role in disease.
Abstract: Department of Chemistry, The Johns Hopkins University, Charles and 34th Streets, Baltimore, Maryland 21218, Kluyver Laboratory for Biotechnology, Delft University of Technology, 2628 BC Delft, The Netherlands, Department of Biochemistry and Molecular Biology, OGI School of Science and Engineering at OHSU, Beaverton, Oregon 97006, and Department of Microbiology and Molecular Genetics, University of California, Los Angeles, California 90095
400 citations
TL;DR: Introduction 13103 CationicSequences 13104 Anionic Sequences 13106 3a.
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195 citations
TL;DR: It is shown here how ring closure of the Two-Carbon Bridge and Ring Expansion of Bicyclo[2.2.1]heptanes and Fragmentations Leading to Nonbridged Carbocycles 63 leading to Reactivity 63 can be modelled.
Abstract: b. Ring Closures of the Two-Carbon Bridge 42 c. Ring Closures of the One-Carbon Bridge 44 9. Free Radical-based Methods 44 a. Reductive Methods 44 b. Oxidative Methods 47 10. Organometallic-Based Methods 48 a. Iron Carbonyl Chemistry 48 b. Palladium Chemistry 49 11. Miscellaneous Methods 50 a. Wittig Olefination 50 b. Photochemical Rearrangements 51 c. Prins Reaction 51 IV. Cycloadditions and Other Electrocyclizations 51 1. [4+2] Cycloadditions 51 2. [5+2] Cycloadditions 52 3. [4+3] Cycloadditions 53 4. [3+2] Cycloadditions 54 5. [2+2+2] Cycloadditions 54 6. Ene-Type Cyclizations 54 7. Sigmatropic Rearrangements 55 V. Ring Expansion of Bicyclo[2.2.1]heptanes 55 VI. Rearrangement of Polycyclic Intermediates 58 1. Isomerization of Bicyclo[2.2.2]octanes 58 2. From Cyclopropane-Containing Intermediates 60 3. From Cyclobutane-Containing Intermediates 61 4. From Bridged Bicyclononane Precursors 62 VII. Reactivity 63 1. Fragmentations Leading to Nonbridged Carbocycles 63
159 citations