Journal ArticleDOI
Novel Coumarin and 4H-Chromene Derivatives Containing 4,5- Dihydropyrazole Moiety: Synthesis and Antibacterial Activity
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This article is published in Letters in Drug Design & Discovery.The article was published on 2011-06-30. It has received 14 citations till now. The article focuses on the topics: Moiety & Antibacterial activity.read more
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Synthesis of coumarin-based 1,3,4-oxadiazol-2ylthio-N-phenyl/benzothiazolyl acetamides as antimicrobial and antituberculosis agents
TL;DR: This study shows to what extent the presence of various electron withdrawing/donating substituents on the phenyl or benzothiazole ring affects the activity profiles of the newer molecules.
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The anti-proliferative activity of novel 4H-benzo[h]chromenes, 7H-benzo[h]-chromeno[2,3-d]pyrimidines and the structure–activity relationships of the 2-, 3-positions and fused rings at the 2, 3-positions
TL;DR: The SAR study revealed that the antitumor activity of the synthesized compounds was significantly affected by the lipophilicity (hydrophobic or hydrophilic) of the substituent at 2- or 3- and 2, 3-positions.
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Structural Characterization and Antimicrobial Activities of 7H-Benzo[h]chromeno[2,3-d]pyrimidine and 14H-Benzo[h]chromeno[3,2-e][1,2,4]triazolo[1,5-c] pyrimidine Derivatives
Rawda M. Okasha,Fawzia F Albalawi,Tarek H. Afifi,Ahmed M. Fouda,Al-Anood M. Al-Dies,Ahmed M. El-Agrody +5 more
TL;DR: It was demonstrated that 7H-benzochromenopyrimidine and derivatives of 14H- Benzylideneamino-7-(4-halo-phenyl)-5-methoxy-8-imino-9-benzo-[h]chromeno[2,3-d]pyrimidines 8a–b exhibited the most promising antibacterial activities compared to the reference antimicrobial agents.
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Synthesis, in-vitro cytotoxicity of 4H-benzo[h]chromene derivatives and structure—activity relationships of 4-aryl group and 3-, 7-positions
TL;DR: The structure-activity relationship of 4H-benzo[h]chromenes with modification at the 3-, 4- and 7-positions was explored and the results of the anti-tumour evaluation revealed that compounds VIIIc, VIId, VIIb, VIIe, VIIIg and VIII c inhibited the growth of MCF-7 in comparison with vinblastine and colchicine, respectively.
Journal ArticleDOI
Coumarin derivatives as potential inhibitors of acetylcholinesterase: Synthesis, molecular docking and biological studies.
Shaffali Singla,Poonam Piplani +1 more
TL;DR: Molecular docking study of compound 15a indicated that it interacts with all the crucial amino acids present at the CAS, mid-gorge and PAS of TcAChE resulting in increased inhibition of AChE enzyme.