Journal ArticleDOI
Novel drug delivery methods for improving efficacy of endometriosis treatments.
Simone Garzon,Antonio Simone Laganà,Fabio Barra,Jvan Casarin,Antonella Cromi,Ricciarda Raffaelli,Stefano Uccella,Massimo Franchi,Fabio Ghezzi,Simone Ferrero +9 more
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TLDR
This review aims to provide the reader with a complete overview of available evidence about alternative and novel drug delivery methods for endometriosis pharmacotherapy and highlight new research lines.Abstract:
Pharmacotherapy has a key role in the management of endometriosis. However, a significant proportion of patients gains only intermittent or limited benefits. In this regard, alternative and novel d...read more
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Linzagolix: a new GnRH-antagonist under investigation for the treatment of endometriosis and uterine myomas.
Susan Dababou,Simone Garzon,Antonio Simone Laganà,Simone Ferrero,Giulio Evangelisti,Marco Noventa,Maurizio Nicola D'Alterio,Stefano Palomba,Stefano Uccella,Massimo Franchi,Fabio Barra +10 more
TL;DR: Uterine myomas and endometriosis are benign hormone dependent diseases affecting women of reproductive age as mentioned in this paper, and substantial efforts have been made to develop innovative medical options for treating the...
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Desogestrel only contraceptive pill versus sequential contraceptive vaginal ring in the treatment of rectovaginal endometriosis infiltrating the rectum: a prospective open-label comparative study
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Erratum to “Subject and clinician experience with the levonorgestrel-releasing intrauterine system”
TL;DR: Over 95% of women had successful insertions of the LNG IUS at first attempt, and less than 1% were unsuccessful after two attempts, and one-year continuation rates were comparable to those of other reversible methods.
Journal ArticleDOI
Aromatase inhibitors for the treatment of endometriosis: a systematic review about efficacy, safety and early clinical development.
Simone Garzon,Antonio Simone Laganà,Fabio Barra,Jvan Casarin,Antonella Cromi,Ricciarda Raffaelli,Stefano Uccella,Massimo Franchi,Fabio Ghezzi,Simone Ferrero +9 more
TL;DR: Based on the critical role of estrogens and the rate-limiting step in the production of the estrogens represented by the aromatase enzyme, AIs are a potential therapeutic option for women affected by endometriosis, but further research is needed to clarify the efficacy and safety of AIs.
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Identification of lesional attributes of dysmenorrhea severity and the serum antimüllerian hormone levels in women with ovarian endometriomas.
TL;DR: In this article , the extent of lesional fibrosis was positively correlated with the severity of dysmenorrhea but had no impact on the serum antimüllerian hormone (AMH) levels.
References
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Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier
TL;DR: This manuscript describes the various fabrication techniques for these devices and the factors affecting their degradation and drug release.
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ESHRE guideline: management of women with endometriosis
Gerard A.J. Dunselman,Nathalie Vermeulen,Christian M. Becker,Carlos Calhaz-Jorge,B. De Bie,O. Heikinheimo,L. Kiesel,Annemiek W. Nap,Andrew M. Prentice,Ertan Saridogan,David Soriano,Willianne L.D.M. Nelen +11 more
TL;DR: This guideline was produced by a group of experts in the field using the structured methodology of the Manual for ESHRE Guideline Development, including a thorough systematic search of the literature, quality assessment of the included papers up to January 2012 and consensus within the guideline group on all recommendations.
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Clinical practice. endometriosis
TL;DR: A healthy 25-year-old woman presents with worsening dysmenorrhea, pain of recent onset in the left lower quadrant, and dyspareunia.
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Development and Maintenance of Regulatory T cells
TL;DR: Understanding how epigenetic alterations and Foxp3 expression coordinately control Treg-cell-specific gene regulation will enable better control of immune responses by targeting the generation and maintenance of Treg cells.
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Blockade of CTLA-4 on CD4+CD25+ regulatory T cells abrogates their function in vivo.
Simon Read,Rebecca J. Greenwald,Ana Izcue,Nicholas J. Robinson,Didier A. Mandelbrot,Loise M. Francisco,Arlene H. Sharpe,Fiona Powrie +7 more
TL;DR: Direct evidence that CTLA-4 has a specific, nonredundant role in the function of normal TR is provided, as such a strategy will not only boost effector T cell responses, but might also break TR-mediated self-tolerance.